EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
[HTML][HTML] Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer
Epidermal growth factor receptor (EGFR) mutations are the second most common oncogenic
driver event in non-small cell lung cancer (NSCLC). Classical activating mutations (exon 19 …
driver event in non-small cell lung cancer (NSCLC). Classical activating mutations (exon 19 …
[HTML][HTML] Recent advances on the role of EGFR tyrosine kinase inhibitors in the management of NSCLC with uncommon, non exon 20 insertions, EGFR mutations
The first-line treatment of choice for patients with epidermal growth factor receptor (EGFR)
mutation-positive non-small cell lung cancer (NSCLC) is an EGFR tyrosine kinase inhibitor …
mutation-positive non-small cell lung cancer (NSCLC) is an EGFR tyrosine kinase inhibitor …
[HTML][HTML] Receptor tyrosine kinase-targeted cancer therapy
T Yamaoka, S Kusumoto, K Ando, M Ohba… - International journal of …, 2018 - mdpi.com
In the past two decades, several molecular targeted inhibitors have been developed and
evaluated clinically to improve the survival of patients with cancer. Molecular targeted …
evaluated clinically to improve the survival of patients with cancer. Molecular targeted …
[HTML][HTML] Heterogeneous responses to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with uncommon EGFR mutations: new …
A Russo, T Franchina, G Ricciardi, A Battaglia… - International Journal of …, 2019 - mdpi.com
Uncommon Epidermal Growth Factor Receptor (EGFR) mutations represent a distinct and
highly heterogeneous subgroup of Non-Small Cell Lung Cancers (NSCLCs), that accounts …
highly heterogeneous subgroup of Non-Small Cell Lung Cancers (NSCLCs), that accounts …
[HTML][HTML] Efficacy and safety of afatinib for EGFR-mutant non-small cell lung cancer, compared with gefitinib or erlotinib
Y Kim, SH Lee, JS Ahn, MJ Ahn… - Cancer Research and …, 2019 - synapse.koreamed.org
Purpose We tried to evaluate whether there are any specific features in treatment outcomes
of firstline afatinib in patients with epidermal growth factor receptor (EGFR)-mutant non-small …
of firstline afatinib in patients with epidermal growth factor receptor (EGFR)-mutant non-small …
Comparing the effects of afatinib with gefitinib or Erlotinib in patients with advanced-stage lung adenocarcinoma harboring non-classical epidermal growth factor …
Abstract Objective Approximately 10%–15% patients with epidermal growth factor receptor
(EGFR) mutations harbor non-classical mutations. However, the effects of EGFR-tyrosine …
(EGFR) mutations harbor non-classical mutations. However, the effects of EGFR-tyrosine …
[HTML][HTML] Treatment strategies for non-small cell lung cancer harboring common and uncommon EGFR mutations: drug sensitivity based on exon classification, and …
R Kitadai, Y Okuma - Cancers, 2022 - mdpi.com
Simple Summary The advent of epidermal growth factor receptor (EGFR) tyrosine kinase
inhibitors (EGFR-TKIs) has led to a dramatic improvement in the prognosis of patients …
inhibitors (EGFR-TKIs) has led to a dramatic improvement in the prognosis of patients …
[HTML][HTML] Non-small cell lung cancer harbouring non-resistant uncommon EGFR mutations: Mutation patterns, effectiveness of epidermal growth factor receptor-tyrosine …
LC Chang, CK Lim, LY Chang, KY Chen… - European Journal of …, 2019 - Elsevier
Introduction Non-small cell lung cancer (NSCLC) harbouring EGFR exon 19 deletions or
L858R mutation usually respond to epidermal growth factor receptor–tyrosine kinase …
L858R mutation usually respond to epidermal growth factor receptor–tyrosine kinase …
Uncommon EGFR mutations associate with lower incidence of T790M mutation after EGFR-TKI treatment in patients with advanced NSCLC
S Yang, S Mao, X Li, C Zhao, Q Liu, X Yu, Y Wang… - Lung Cancer, 2020 - Elsevier
Objectives Advanced non-small cell lung cancer (NSCLC) patients harboring non-resistant
uncommon epidermal growth factor receptor (EGFR) mutations have stepped into the era of …
uncommon epidermal growth factor receptor (EGFR) mutations have stepped into the era of …