Tuberous sclerosis (TSC) is a neurocutaneous disorder with an autosomal-dominant pattern
of inheritance and is caused by heterozygous mutations in the TSC1 or TSC2 gene …

Background: Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal tumor,
located at various anatomic sites, including the female genital tract. This study aimed to …

Tuberous sclerosis complex (TSC) is a genetic disorder with a high prevalence of autism
spectrum disorder (ASD). Tremendous progress in understanding the pathogenesis of TSC …

Significant developments in the use of mammalian target of rapamycin (mTOR) inhibitors
(mTORIs) as immunosuppressant and antiproliferative agents have been made. Recent …

The plethora of novel molecular-targeted agents (MTAs) has provided an opportunity to
selectively target pathways involved in carcinogenesis and tumour progression …

The updated diagnostic criteria and management guidelines, the new concept of TAND and
the TAND Checklist should lead to significant improvements in the quality of care for …

Abstract Background The severity of Tuberous Sclerosis Complex (TSC) can vary among
affected individuals. Complications of TSC can be life threatening, with significant impact on …

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder characterized by the
development of hamartomas in several organs. Mutations in the TSC1 and TSC2 tumor …

Hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) is a feature of
many solid tumours and is a key pathogenic driver in the inherited condition Tuberous …

Tuberous sclerosis complex (TSC) is a rare multisystem disorder, primary manifestations of
which are benign tumors and lesions in various organs of the body, including the brain. TSC …