Lung endothelium, tau, and amyloids in health and disease

R Balczon, MT Lin, S Voth, AR Nelson… - Physiological …, 2024 - journals.physiology.org
Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

[HTML][HTML] Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer's disease and normal physiology

G Pfundstein, AG Nikonenko, V Sytnyk - Frontiers in cell and …, 2022 - frontiersin.org
Alzheimer's disease (AD) is an incurable neurodegenerative disorder in which dysfunction
and loss of synapses and neurons lead to cognitive impairment and death. Accumulation …

[HTML][HTML] Human microRNA (miR-20b-5p) modulates Alzheimer's disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene …

R Wang, N Chopra, K Nho, B Maloney… - Molecular …, 2022 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with loss of cognitive,
executive, and other mental functions, and is the most common form of age-related …

The microglial lysosomal system in Alzheimer's disease: Guardian against proteinopathy

ZP Van Acker, A Perdok, M Bretou, W Annaert - Ageing Research Reviews, 2021 - Elsevier
Microglia, the brain-resident immune cells, play an essential role in the upkeep of brain
homeostasis. They actively adapt into specific activation states based on cues from the …

[HTML][HTML] Brain vasculature disturbance in schizophrenia

S Puvogel, V Palma, IEC Sommer - Current opinion in psychiatry, 2022 - journals.lww.com
In some patients with SZ, a vulnerable brain endothelium may be interacting with
environmental stressors, such as inflammation or hypoxia, converging into a more severe SZ …

[HTML][HTML] Vascular Signalling

S Dragoni, P Turowski - Cells, 2023 - mdpi.com
In all vertebrates, closed blood and open lymph circulatory systems are essential for the
delivery of nutrients and oxygen to tissues, waste clearance, and immune function …

[HTML][HTML] Single-cell transcriptome profiling highlights the role of APP in blood vessels in assessing the risk of patients with proliferative diabetic retinopathy developing …

X Xu, C Zhang, G Tang, N Wang… - Frontiers in Cell and …, 2024 - frontiersin.org
Introduction: The incidence of diabetic retinopathy (DR) has been found to be associated
with the risk of developing Alzheimer's disease (AD). In addition to the common properties of …

The structure of an Amyloid Precursor Protein/talin complex indicates a mechanical basis of Alzheimer's disease

C Ellis, NL Ward, M Rice, NJ Ball, JC Lambert… - bioRxiv, 2024 - biorxiv.org
Abstract Misprocessing of Amyloid Precursor Protein (APP) is one of the major causes of
Alzheimer's disease. APP is a transmembrane protein comprising a large extracellular …

[HTML][HTML] Transcription of the envelope protein by 1-L protein–RNA recognition code leads to genes/proteins that are relevant to the SARS-CoV-2 life cycle and …

J Nahalka - Current Issues in Molecular Biology, 2022 - mdpi.com
The theoretical protein–RNA recognition code was used in this study to research the
compatibility of the SARS-CoV-2 envelope protein (E) with mRNAs in the human …

[HTML][HTML] Promising Support Coming from Nature: Antioxidant and Anti-Inflammatory Potential of Castanea sativa Wood Distillate on Skin Cells

A Filippelli, V Ciccone, S Loppi, L Morbidelli - Current Issues in Molecular …, 2024 - mdpi.com
Tissue homeostasis, function recovery, and protection mechanisms are boosted by the
balanced and timely control of inflammation and oxidative stress. Nowadays, many natural …