Lung endothelium, tau, and amyloids in health and disease
Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …
[HTML][HTML] Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer's disease and normal physiology
Alzheimer's disease (AD) is an incurable neurodegenerative disorder in which dysfunction
and loss of synapses and neurons lead to cognitive impairment and death. Accumulation …
and loss of synapses and neurons lead to cognitive impairment and death. Accumulation …
[HTML][HTML] Human microRNA (miR-20b-5p) modulates Alzheimer's disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with loss of cognitive,
executive, and other mental functions, and is the most common form of age-related …
executive, and other mental functions, and is the most common form of age-related …
The microglial lysosomal system in Alzheimer's disease: Guardian against proteinopathy
ZP Van Acker, A Perdok, M Bretou, W Annaert - Ageing Research Reviews, 2021 - Elsevier
Microglia, the brain-resident immune cells, play an essential role in the upkeep of brain
homeostasis. They actively adapt into specific activation states based on cues from the …
homeostasis. They actively adapt into specific activation states based on cues from the …
[HTML][HTML] Brain vasculature disturbance in schizophrenia
S Puvogel, V Palma, IEC Sommer - Current opinion in psychiatry, 2022 - journals.lww.com
In some patients with SZ, a vulnerable brain endothelium may be interacting with
environmental stressors, such as inflammation or hypoxia, converging into a more severe SZ …
environmental stressors, such as inflammation or hypoxia, converging into a more severe SZ …
[HTML][HTML] Vascular Signalling
S Dragoni, P Turowski - Cells, 2023 - mdpi.com
In all vertebrates, closed blood and open lymph circulatory systems are essential for the
delivery of nutrients and oxygen to tissues, waste clearance, and immune function …
delivery of nutrients and oxygen to tissues, waste clearance, and immune function …
[HTML][HTML] Single-cell transcriptome profiling highlights the role of APP in blood vessels in assessing the risk of patients with proliferative diabetic retinopathy developing …
X Xu, C Zhang, G Tang, N Wang… - Frontiers in Cell and …, 2024 - frontiersin.org
Introduction: The incidence of diabetic retinopathy (DR) has been found to be associated
with the risk of developing Alzheimer's disease (AD). In addition to the common properties of …
with the risk of developing Alzheimer's disease (AD). In addition to the common properties of …
The structure of an Amyloid Precursor Protein/talin complex indicates a mechanical basis of Alzheimer's disease
C Ellis, NL Ward, M Rice, NJ Ball, JC Lambert… - bioRxiv, 2024 - biorxiv.org
Abstract Misprocessing of Amyloid Precursor Protein (APP) is one of the major causes of
Alzheimer's disease. APP is a transmembrane protein comprising a large extracellular …
Alzheimer's disease. APP is a transmembrane protein comprising a large extracellular …
[HTML][HTML] Transcription of the envelope protein by 1-L protein–RNA recognition code leads to genes/proteins that are relevant to the SARS-CoV-2 life cycle and …
J Nahalka - Current Issues in Molecular Biology, 2022 - mdpi.com
The theoretical protein–RNA recognition code was used in this study to research the
compatibility of the SARS-CoV-2 envelope protein (E) with mRNAs in the human …
compatibility of the SARS-CoV-2 envelope protein (E) with mRNAs in the human …
[HTML][HTML] Promising Support Coming from Nature: Antioxidant and Anti-Inflammatory Potential of Castanea sativa Wood Distillate on Skin Cells
Tissue homeostasis, function recovery, and protection mechanisms are boosted by the
balanced and timely control of inflammation and oxidative stress. Nowadays, many natural …
balanced and timely control of inflammation and oxidative stress. Nowadays, many natural …