Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical Reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

X Zhao, J Liu, J Fan, H Chao, X Peng - Chemical Society Reviews, 2021 - pubs.rsc.org
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …

Visible-to-NIR-light activated release: from small molecules to nanomaterials

R Weinstain, T Slanina, D Kand, P Klan - Chemical reviews, 2020 - ACS Publications
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Transition metal complexes and photodynamic therapy from a tumor-centered approach: challenges, opportunities, and highlights from the development of TLD1433

S Monro, KL Colon, H Yin, J Roque III, P Konda… - Chemical …, 2018 - ACS Publications
Transition metal complexes are of increasing interest as photosensitizers in photodynamic
therapy (PDT) and, more recently, for photochemotherapy (PCT). In recent years, Ru (II) …

Rationally designed ruthenium complexes for 1-and 2-photon photodynamic therapy

J Karges, S Kuang, F Maschietto, O Blacque… - Nature …, 2020 - nature.com
The use of photodynamic therapy (PDT) against cancer has received increasing attention
over recent years. However, the application of the currently approved photosensitizers (PSs) …

Stimuli-responsive therapeutic metallodrugs

X Wang, X Wang, S Jin, N Muhammad, Z Guo - Chemical reviews, 2018 - ACS Publications
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

The development of anticancer ruthenium (II) complexes: from single molecule compounds to nanomaterials

L Zeng, P Gupta, Y Chen, E Wang, L Ji… - Chemical Society …, 2017 - pubs.rsc.org
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …

A Near‐Infrared Light‐Activated Photocage Based on a Ruthenium Complex for Cancer Phototherapy

G He, M He, R Wang, X Li, H Hu… - Angewandte Chemie …, 2023 - Wiley Online Library
Conventional photocages only respond to short wavelength light, which is a significant
obstacle to developing efficient phototherapy in vivo. The development of photocages …

Combination of light and Ru (II) polypyridyl complexes: Recent advances in the development of new anticancer drugs

L Conti, E Macedi, C Giorgi, B Valtancoli… - Coordination Chemistry …, 2022 - Elsevier
The increasing impact of cancer on worldwide mortality makes the research of novel
chemotherapeutic agents a current and challenging issue. In the recent years, transition …

The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

FE Poynton, SA Bright, S Blasco, DC Williams… - Chemical Society …, 2017 - pubs.rsc.org
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …