Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

[HTML][HTML] Age-related macular degeneration: epidemiology, pathophysiology, diagnosis, and treatment

H Vyawahare, P Shinde - Cureus, 2022 - ncbi.nlm.nih.gov
The greatest global root of irremediable amaurosis in the venerable is age-related macular
degeneration (AMD), a complex eye condition. Clinically, AMD is characterized as being in …

[HTML][HTML] Kaempferol: Paving the path for advanced treatments in aging-related diseases

MS Hussain, ASA Altamimi, M Afzal, WH Almalki… - Experimental …, 2024 - Elsevier
Aging-related diseases (ARDs) are a major global health concern, and the development of
effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has …

[HTML][HTML] Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury

WH Moos, DV Faller, IP Glavas, DN Harpp… - Biochemical …, 2022 - Elsevier
Pathological deterioration of mitochondrial function is increasingly linked with multiple
degenerative illnesses as a mediator of a wide range of neurologic and age-related chronic …

Targeting the complement cascade for treatment of dry age-related macular degeneration

PN Patel, PA Patel, MR Land, I Bakerkhatib-Taha… - Biomedicines, 2022 - mdpi.com
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in
the elderly population. AMD is characterized in its late form by neovascularization (wet type) …

[HTML][HTML] Crosstalk between microglia and Müller glia in the age-related macular degeneration: role and therapeutic value of neuroinflammation

N Zhao, XN Hao, JM Huang, ZM Song, Y Tao - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Age-related macular degeneration (AMD) is a progressive neurodegeneration disease that
causes photoreceptor demise and vision impairments. In AMD pathogenesis, the primary …

Dysregulation of resolvin E1 metabolism and signaling in a light-damage model of age-related macular degeneration

A Tisi, G Carozza, A Leuti, R Maccarone… - International Journal of …, 2023 - mdpi.com
Resolvin E1 (RvE1) is an eicosapentaenoic acid-derived lipid mediator involved in the
resolution of inflammation. Here, we investigated whether RvE1 alterations may occur in an …

[HTML][HTML] The Impact of diabetic retinopathy on the choriocapillaris in neovascular AMD

P Viggiano, A Miere, E Borrelli, G Boscia… - … & Visual Science, 2023 - jov.arvojournals.org
Purpose: To investigate the impact of diabetic retinopathy (DR) on morphological
choriocapillaris (CC) modifications in eyes with type 1 macular neovascularization (MNV) …

Oxidative stress and aging: synergies for age related diseases

DF Santos, S Simão, C Nóbrega, J Bragança… - FEBS …, 2024 - Wiley Online Library
Aging is characterized by a progressive decline in physiological function and underlies
several disabilities, including the increased sensitivity of cells and tissues to undergo …

The connection between epigenetics and gut microbiota‐current perspective

X Yuan, Y Tan, O Bajinka, ML Jammeh… - Cell Biochemistry …, 2024 - Wiley Online Library
Both the epigenetic changes and gut microbiota (GM) have attracted a growing interest in
establishing effective diagnostics and potential therapeutic strategies for a number of …