The interplay of oncogenic signaling, oxidative stress and ferroptosis in cancer

W Zeng, X Long, PS Liu, X Xie - International Journal of Cancer, 2023 - Wiley Online Library
Oncogene‐induced hyper‐proliferation in cancer cells is accompanied by the onset of
different stresses, including DNA‐replication stress, metabolic stress and oxidative stress …

Targeting lipid metabolism for ferroptotic cancer therapy

M Luo, J Yan, X Hu, H Li, H Li, Q Liu, Y Chen, Z Zou - Apoptosis, 2023 - Springer
It has been 10 years since the concept of ferroptosis was put forward and research focusing
on ferroptosis has been increasing continuously. Ferroptosis is driven by iron-dependent …

[HTML][HTML] Deciphering the potential roles of ferroptosis in regulating tumor immunity and tumor immunotherapy

X Gu, Y Liu, X Dai, YG Yang, X Zhang - Frontiers in Immunology, 2023 - frontiersin.org
Cancer immunotherapies, including immune checkpoint inhibition (ICI) and adoptive
immune cells therapy, are promising therapeutic strategies. They reactivate the function of …

Ferroptosis-driven nanotherapeutics to reverse drug resistance in tumor microenvironment

L Zhu, D Meng, X Wang, X Chen - ACS Applied Bio Materials, 2022 - ACS Publications
Ferroptosis, characterized by iron-dependent lipid reactive oxygen species (ROS)
accumulation, is non-apoptotic programmed cell death highly relevant to tumor …

[HTML][HTML] Ferroptosis: A new regulatory mechanism in neuropathic pain

L Li, L Guo, R Gao, M Yao, X Qu, G Sun… - Frontiers in aging …, 2023 - frontiersin.org
Neuropathic pain (NP) is pain caused by damage to the somatosensory system. It is a
common progressive neurodegenerative disease that usually presents with clinical features …

[HTML][HTML] Glycolysis-related LINC02432/hsa-miR-98–5p/HK2 axis inhibits ferroptosis and predicts immune infiltration, tumor mutation burden, and drug sensitivity in …

P Tan, M Li, Z Liu, T Li, L Zhao, W Fu - Frontiers in Pharmacology, 2022 - frontiersin.org
Pancreatic adenocarcinoma (PAAD) is a malignant cancer with high incidence and mortality.
Glycometabolic rearrangements (aerobic glycolysis) is a hallmark of PAAD and contributes …

[HTML][HTML] KDELC2 upregulates glioblastoma angiogenesis via reactive oxygen species activation and tumor-associated macrophage proliferation

YL Tsai, Y Chen, YC Chen, WC Tsai - Antioxidants, 2023 - mdpi.com
Glioblastoma is notorious for its rapid progression and neovascularization. In this study, it
was found that KDEL (Lys-Asp-Glu-Leu) containing 2 (KDELC2) stimulated vasculogenic …

Ferroptosis and its Modulators: A Raising Target for Cancer and Alzheimer's Disease

G Singh, P Kesharwani, GK Singh, S Kumar… - Bioorganic & Medicinal …, 2023 - Elsevier
The process of ferroptosis, a recently identified form of regulated cell death (RCD) is
associated with the overloading of iron species and lipid-derived ROS accumulation …

[HTML][HTML] Study of Ferroptosis transmission by small extracellular vesicles in epithelial ovarian cancer cells

C Alarcón-Veleiro, R Mato-Basalo, S Lucio-Gallego… - Antioxidants, 2023 - mdpi.com
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. The current
treatment for EOC involves surgical debulking of the tumors followed by a combination of …

[HTML][HTML] STARD12/14 are diagnostic and prognostic biomarkers of lung adenocarcinoma associated with epigenetic regulation, immune infiltration and ferroptosis

WD Zhang, DM Hu, ZE Shi, QX Wang… - … Journal of Medical …, 2023 - ncbi.nlm.nih.gov
Background: Metabolic reprogramming plays an important role in tumor progression and
antitumor immunity. START domain-containing proteins (STARDs) are responsible for lipid …