Introduction Hepatocellular carcinoma (HCC) remains a frequently diagnosed malignancy
worldwide, still representing an important cause of cancer-related death. Recent years have …

As a pharmacologically important heterocycle, oxadiazole paved the way to combat the
problem associated with the confluence of many commercially available drugs with different …

Trastuzumab deruxtecan (DS-8201) is an antibody–drug conjugate composed of a
humanized monoclonal anti-HER2 antibody, a cleavable tetrapeptide-based linker and a …

Ampullary carcinomas (ACs) represent a rare entity, accounting for approximately 0.2% of all
gastrointestinal solid tumors and 20% of all periampullary cancers (PACs). Unfortunately …

Aim To investigate the oncogenic role of FGFR2 in carcinogenesis in cholangiocarcinoma
(CCA) cells. In addition, the feasibility of using FGFR inhibitors in combination with standard …

Simple Summary Human epidermal growth factor receptor-2 (HER2) plays a critical role in
breast and gastric cancer. More recently, a growing body of literature demonstrated that …

Introduction Cholangiocarcinoma (CCA) frequently presents with an advanced disease
precluding curative surgery and shows modest response to chemotherapy. Advancements …

Cholangiocarcinomas (CCAs) are a heterogenous group of hepatobiliary tumors with poor
prognosis and limited therapeutic options. In the last decade, the advent of genomic profiling …

Endometrial cancer (EC) is one of the most common gynecologic cancers worldwide. There
were 417,367 newly diagnosed cases and 97,370 deaths due to this disease worldwide in …

Biliary tract cancers (BTCs) are rare and heterogeneous malignant tumours including
cholangiocarcinoma and gallbladder cancer. They are very aggressive, often refractory to …