Decades of research have established the toxicity of soot particles resulting from incomplete
combustion. However, the unique chemical compounds responsible for adverse health …

Chemical modifications of DNA and RNA regulate genome functions or trigger mutagenesis
resulting in aging or cancer. Oxidations of macromolecules, including DNA, are common …

In mammalian cells, mature tRNAs are cleaved by stress-activated ribonuclease angiogenin
to generate 5′-and 3′-tRNA halves: a novel class of small non-coding RNAs of 30–40 …

Objectives Recent studies have shown that tRNA-derived RNA fragments (tRFs) are novel
regulators of post-transcriptional gene expression. However, the expression profiles and …

The advent of next-generation sequencing technologies has not only accelerated findings
on various novel non-coding RNA (ncRNA) species but also led to the revision of the …

The biological roles of RNA modifications are still largely not understood. Thus, developing
a method for detecting RNA modifications is important for further clarification. We developed …

Background Mature sperm carry thousands of RNAs, including mRNAs, lncRNAs, tRNAs,
rRNAs and sncRNAs, though their functional significance is still a matter of debate. Growing …

Abstract Transfer (t) RNAs are 70–90 nucleotide small RNAs highly regulated by 43 different
types of epitranscriptomic modifications and requiring aminoacylation ('charging') for mRNA …

Transfer RNA (tRNA) plays a role in stress response programs involved in various
pathological conditions including neurological diseases. Under cell stress conditions …

Endogenous biomarkers are emerging to advance clinical drug‐drug interaction (DDI) risk
assessment in drug development. Twelve healthy subjects received a multidrug and toxin …