Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation
Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …
Hypoxia signaling in human diseases and therapeutic targets
Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia
signaling pathway have been performed. The role of HIF stabilization during hypoxia has …
signaling pathway have been performed. The role of HIF stabilization during hypoxia has …
Targeting metabolic dysregulation for fibrosis therapy
Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
Lung myofibroblasts promote macrophage profibrotic activity through lactate-induced histone lactylation
Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …
[HTML][HTML] Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. It is
characterized by deposition of extracellular matrix proteins, like collagen and fibronectin in …
characterized by deposition of extracellular matrix proteins, like collagen and fibronectin in …
HIF‐1α ameliorates tubular injury in diabetic nephropathy via HO‐1–mediated control of mitochondrial dynamics
N Jiang, H Zhao, Y Han, L Li, S Xiong, L Zeng… - Cell …, 2020 - Wiley Online Library
Objectives In diabetic nephropathy (DN), hypoxia‐inducible factor‐1α (HIF‐1α) activation in
tubular cells plays an important protective role against kidney injury. The effects may occur …
tubular cells plays an important protective role against kidney injury. The effects may occur …
[HTML][HTML] Cardiac Fibrosis in heart failure: Focus on non-invasive diagnosis and emerging therapeutic strategies
S Ravassa, B López, TA Treibel, G San José… - Molecular Aspects of …, 2023 - Elsevier
Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …
resulting from the excessive deposition of collagen fibers, is a common feature across the …
Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis
B Selvarajah, I Azuelos, D Anastasiou… - Science Signaling, 2021 - science.org
Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …
[HTML][HTML] Dysregulation of metabolic pathways in pulmonary fibrosis
R Rajesh, R Atallah, T Bärnthaler - Pharmacology & Therapeutics, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder of unknown origin and
the most common interstitial lung disease. It progresses with the recruitment of fibroblasts …
the most common interstitial lung disease. It progresses with the recruitment of fibroblasts …
Fibroblast senescence in idiopathic pulmonary fibrosis
Y Lin, Z Xu - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Aging is an inevitable and complex natural phenomenon due to the increase in age. Cellular
senescence means a non-proliferative but viable cellular physiological state. It is the basis of …
senescence means a non-proliferative but viable cellular physiological state. It is the basis of …