Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior.
Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes …

Identifying secreted mediators that drive the cognitive benefits of exercise holds great
promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here …

Microglia play a critical role in brain homeostasis and disease progression. In
neurodegenerative conditions, microglia acquire the neurodegenerative phenotype (MGnD) …

Microglia maintain homeostasis in the central nervous system through phagocytic clearance
of protein aggregates and cellular debris. This function deteriorates during ageing and …

An aged circulatory environment can activate microglia, reduce neural precursor cell activity
and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate …

Numerous studies have emphasised the importance of the gut microbiota during early life
and its role in modulating neurodevelopment and behaviour. Epidemiological studies have …

Ethologically relevant behavioral testing is a critical component of any study that uses
mouse models to study the cognitive effects of various physiological or pathological …

Key points Alzheimer's disease (AD) patients and transgenic mice have beta‐amyloid (Aβ)
aggregation in the gastrointestinal (GI) tract. It is possible that Aβ from the periphery …

Tumor necrosis factor-α (TNF-α) is a pleiotropic, proinflammatory cytokine related to different
neurodegenerative diseases, including Alzheimer's disease (AD). Although the linkage …