Interplay between diet, the gut microbiome, and atherosclerosis: Role of dysbiosis and microbial metabolites on inflammation and disordered lipid metabolism

L Anto, CN Blesso - The Journal of Nutritional Biochemistry, 2022 - Elsevier
Atherosclerosis remains the leading cause of death worldwide. Lifestyle modification,
including diet and exercise, is recommended to be the primary prevention strategy for …

Membrane lipids from gut microbiome-associated bacteria as structural and signalling molecules

E Ryan, SA Joyce, DJ Clarke - Microbiology, 2023 - microbiologyresearch.org
Bacteria produce an array of diverse, dynamic and often complex lipid structures, some of
which function beyond their typical role in membrane structure. The model organism, E. coli …

Lipidomic Analysis Reveals Differences in Bacteroides Species Driven Largely by Plasmalogens, Glycerophosphoinositols and Certain Sphingolipids

E Ryan, B Gonzalez Pastor, LA Gethings, DJ Clarke… - Metabolites, 2023 - mdpi.com
There has been increasing interest in bacterial lipids in recent years due, in part, to their
emerging role as molecular signalling molecules. Bacteroides thetaiotaomicron is an …

Lipidomic analysis of Porphyromonas gingivalis reveals novel glycerol bisphosphoceramide, phosphatidyl-, and phosphoglycerol dipeptide lipid families

BA Kleiboeker, C Frankfater, ME Davey, FF Hsu - Journal of lipid research, 2023 - ASBMB
Porphyromonas gingivalis, like other members of the phylum Bacteroidetes (synonym
Bacteroidota), synthesizes several classes of dihydroceramides and peptidolipids. Using a …

Lipidome of the Bacteroides Genus Containing New Peptidolipid and Sphingolipid Families Revealed by Multiple-Stage Mass Spectrometry

CF Frankfater, MG Sartorio, E Valguarnera… - Biochemistry, 2023 - ACS Publications
The anaerobic bacteria of the Bacteroides fragilis group including Bacteroides
thetaiotaomicron, B. fragilis, Bacteroides vulgatus, and Bacteroides ovatus in genus …

Structures and functions of the gut microbial lipidome

S Morozumi, M Ueda, N Okahashi, M Arita - Biochimica et Biophysica Acta …, 2022 - Elsevier
Microbial lipids provide signals that are responsible for maintaining host health and
controlling disease. The differences in the structures of microbial lipids have been shown to …

Construction of a bacterial lipidomics analytical platform: Pilot validation with bovine paratuberculosis serum

PL Wood, E Erol - Metabolites, 2023 - mdpi.com
Lipidomics analyses of bacteria offer the potential to detect and monitor infections in a host
since many bacterial lipids are not present in mammals. To evaluate this omics approach …

Spatially resolved lipidomics shows conditional transfer of lipids produced by Bacteroides thetaiotaomicron into the mouse gut

CM Barone, SL Heaver, L Gruber, F Zundel, RE Ley - Cell Host & Microbe, 2024 - cell.com
The extent to which bacterial lipids produced by the gut microbiota penetrate host tissues is
unclear. Here, we combined mass spectrometry approaches to identify lipids produced by …

The multifaceted role of c-di-AMP signaling in the regulation of Porphyromonas gingivalis lipopolysaccharide structure and function

S Ghods, A Muszyński, H Yang, RS Seelan… - Frontiers in Cellular …, 2024 - frontiersin.org
Background This study unveils the intricate functional association between cyclic di-3', 5'-
adenylic acid (c-di-AMP) signaling, cellular bioenergetics, and the regulation of …

Metabolism of serine/glycine lipids by human gingival cells in culture

TM Guido, SD Ratcliffe, A Rahmlow… - Molecular Oral …, 2024 - Wiley Online Library
Porphyromonas gingivalis produces five classes of serine/glycine lipids that are recovered
in lipid extracts from periodontitis‐afflicted teeth and diseased gingival tissues, particularly at …