[HTML][HTML] Role of PI3K-AKT-mTOR pathway as a pro-survival signaling and resistance-mediating mechanism to therapy of prostate cancer
T Pungsrinont, J Kallenbach, A Baniahmad - International journal of …, 2021 - mdpi.com
Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …
gold standard options for treating prostate cancer (PCa). These are initially effective, as …
[HTML][HTML] PTEN Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?
Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a
substantial proportion of solid tumors. These events drive tumorigenesis and tumor …
substantial proportion of solid tumors. These events drive tumorigenesis and tumor …
PTEN‐PI3K pathway alterations in advanced prostate cancer and clinical implications
AD Choudhury - The Prostate, 2022 - Wiley Online Library
Background Despite significant advances in molecular characterization and therapeutic
targeting of advanced prostate cancer, it remains the second most common cause of cancer …
targeting of advanced prostate cancer, it remains the second most common cause of cancer …
[HTML][HTML] Targeting DNA damage response in prostate and breast cancer
AM Wengner, A Scholz, B Haendler - International journal of molecular …, 2020 - mdpi.com
Steroid hormone signaling induces vast gene expression programs which necessitate the
local formation of transcription factories at regulatory regions and large-scale alterations of …
local formation of transcription factories at regulatory regions and large-scale alterations of …
[HTML][HTML] Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response
M Ashrafizadeh, MDA Paskeh, S Mirzaei… - Journal of Experimental …, 2022 - Springer
Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …
[HTML][HTML] Molecular aspects and therapeutic implications of herbal compounds targeting different types of cancer
A Sharma, L Sharma, SK Nandy, N Payal, S Yadav… - Molecules, 2023 - mdpi.com
Due to genetic changes in DNA (deoxyribonucleic acid) sequences, cancer continues to be
the second most prevalent cause of death. The traditional target-directed approach, which is …
the second most prevalent cause of death. The traditional target-directed approach, which is …
[HTML][HTML] Small in size, but large in action: microRNAs as potential modulators of PTEN in breast and lung cancers
AJ Abadi, A Zarrabi, MH Gholami, S Mirzaei… - Biomolecules, 2021 - mdpi.com
MicroRNAs (miRNAs) are well-known regulators of biological mechanisms with a small size
of 19–24 nucleotides and a single-stranded structure. miRNA dysregulation occurs in cancer …
of 19–24 nucleotides and a single-stranded structure. miRNA dysregulation occurs in cancer …
Design, synthesis and molecular docking of novel substituted azepines as inhibitors of PI3K/Akt/TSC2/mTOR signaling pathway in colorectal carcinoma
A series of novel substituted azepines (2–7) was synthesized using both traditional and
ultrasonic techniques. The efficiency of the reaction rate and yield was improved by …
ultrasonic techniques. The efficiency of the reaction rate and yield was improved by …
[HTML][HTML] Exosomes in pathogenesis, diagnosis, and treatment of hepatocellular carcinoma
S Li, L Chen - Frontiers in oncology, 2022 - frontiersin.org
Exosomes are extracellular vesicles with a diameter of 30-150 nm that are released by most
types of cells and have been confirmed to be involved in many physical and pathological …
types of cells and have been confirmed to be involved in many physical and pathological …
[HTML][HTML] Genetic comprehension of organophosphate flame retardants, an emerging threat to prostate cancer
In recent years, organophosphate ester flame retardants (OPFRs), which have been
regarded as alternatives for brominated flame retardants (BFRs), have become widely used …
regarded as alternatives for brominated flame retardants (BFRs), have become widely used …