Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …

Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a
substantial proportion of solid tumors. These events drive tumorigenesis and tumor …

Background Despite significant advances in molecular characterization and therapeutic
targeting of advanced prostate cancer, it remains the second most common cause of cancer …

Steroid hormone signaling induces vast gene expression programs which necessitate the
local formation of transcription factories at regulatory regions and large-scale alterations of …

Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

Due to genetic changes in DNA (deoxyribonucleic acid) sequences, cancer continues to be
the second most prevalent cause of death. The traditional target-directed approach, which is …

MicroRNAs (miRNAs) are well-known regulators of biological mechanisms with a small size
of 19–24 nucleotides and a single-stranded structure. miRNA dysregulation occurs in cancer …

A series of novel substituted azepines (2–7) was synthesized using both traditional and
ultrasonic techniques. The efficiency of the reaction rate and yield was improved by …

Exosomes are extracellular vesicles with a diameter of 30-150 nm that are released by most
types of cells and have been confirmed to be involved in many physical and pathological …

In recent years, organophosphate ester flame retardants (OPFRs), which have been
regarded as alternatives for brominated flame retardants (BFRs), have become widely used …