Bone remodeling is a continuous and dynamic process of bone formation and resorption to
maintain its integrity and homeostasis. Bone marrow is a source of various cell lineages …

Osteosarcoma is the most common malignant primary bone tumor in children and
adolescents. While clinical outcomes have improved, the 5-year survival rate is only around …

Background. Due to the molecular heterogeneity of hepatocellular carcinoma (HCC),
majority of patients respond poorly among various of therapy. This study is aimed at …

Osteosarcoma is a rare bone cancer in adolescents and young adults with a dismal
prognosis because of metastatic disease and chemoresistance. Despite multiple clinical …

Acute lymphoblastic leukemia (ALL) is one of the commonest hematological malignancies
affecting children and adults. Recent evidence suggests an involvement of Epstein-Barr …

Patient-derived xenografts (PDX) remain valuable models for understanding the biology and
for developing novel therapeutics. To expand current PDX models of childhood leukemia …

DNA methylation may be involved in the development of osteosarcomas. Osteosarcomas
commonly arise during the bone growth and remodeling in puberty, making it plausible to …

Epithelial–mesenchymal transition (EMT) plays essential roles in promoting malignant
transformation of epithelial cells, leading to cancer progression and metastasis. During EMT …

DNA methylation is a key epigenetic regulatory mechanism that plays a critical role in a
variety of cellular processes, including the regulation of cell fate during development …

Simple Summary In adults, meningioma is the most common primary tumor of the brain. It is
classified into three clinical grades of aggressiveness. Whereas disease recurrence after …