Coumarins from carcinogenic phenol: synthesis, characterization, in silico, biosafety, anticancer, antioxidant, and anti-inflammatory assessments

YF Mustafa - Chemical Papers, 2024 - Springer
Since 1947, a sterically hindered phenol named 3-(tert-butyl)-4-methoxyphenol, abbreviated
here as 3-tBMP, has been widely used as a powerful preservative antioxidant for food …

Biooriented Synthesis of Ibuprofen-Clubbed Novel Bis-Schiff Base Derivatives as Potential Hits for Malignant Glioma: In Vitro Anticancer Activity and In Silico …

M Ayaz, A Alam, Zainab, M Assad, A Javed… - ACS …, 2023 - ACS Publications
This research work is based on the synthesis of bis-Schiff base derivatives of the
commercially available ibuprofen drug in outstanding yields through multistep reactions …

Coumarins derived from natural methoxystilbene as oxidative stress-related disease alleviators: Synthesis and in vitro-in silico study

YF Mustafa - Journal of Molecular Structure, 2024 - Elsevier
Abstract 3, 4, 5-Trimethoxy-3′-hydroxy-4′-methoxystilbene (TMHMS) is an anticancer
natural stilbene that targets tubulin polymerization. According to research, oxidative stress …

Combretastatin A4-based coumarins: synthesis, anticancer, oxidative stress-relieving, anti-inflammatory, biosafety, and in silico analysis

YF Mustafa - Chemical Papers, 2024 - Springer
A potent natural combretastatin, combretastatin A-4 (COMA4) targets the condylon active
pocket to produce anticancer effects. Studies on inflammation and oxidative stress have …

Synthesis of acetaminophen‐based coumarins as selective COX‐2 inhibitors: An in vitro‐in silico study

MHM Jasim, YF Mustafa - Chemistry & Biodiversity, 2024 - Wiley Online Library
Acetaminophen, a centrally‐acting old analgesic drug, is a weak inhibitor of cyclooxygenase
(COX) isoforms with some selectivity toward COX‐2. This compound was used in this work …

[PDF][PDF] Beyond blood sugar: exploring the anti-inflammatory frontier of antidiabetic medications to alleviate diabetic complications

KA Hadid, FA Alassaf, MN Abed - Romanian Journal of Medical …, 2024 - rjmp.com.ro
Background and objective. Inflammation is closely correlated with diabetes and diabetic
complications. Research has shown that individuals with diabetes exhibit an upregulation of …

The diabetic-anemia nexus: implications for clinical practice

GM Ahmed, MN Abed, FA Alassaf - MMSL, 2023 - mmsl.actavia.cz
Objectives: Due to a variety of factors, individuals with diabetes are more likely to develop
anemia. Chronic kidney disease, a frequent consequence of diabetes, is one of the key …

[HTML][HTML] Synthesis and evaluation of linearly fused thiadiazolocoumarins as prospects with broad-spectrum bioactivity

RN Jibroo, YF Mustafa, W Al-Shakarchi - Results in Chemistry, 2024 - Elsevier
Various pharmacological properties of coumarins brought them under light among the
heterocyclics. Also, coumarin derivatives still approve of their importance in the medical field …

[PDF][PDF] Results in Chemistry

RN Jibroo, YF Mustafa, W Al-Shakarchi - researchgate.net
Various pharmacological properties of coumarins brought them under light among the
heterocyclics. Also, coumarin derivatives still approve of their importance in the medical field …