Novel insights from basic and translational studies are reshaping concepts of the
immunopathogenesis of multiple sclerosis and understanding of the different inflammatory …

The chemokine CXC-ligand 13 (CXCL13) is a major B cell chemoattractant to B cell follicles
in secondary lymphoid organs (SLO) that proposedly recruits B cells to the cerebrospinal …

Neuromyelitis optica spectrum disorders (NMOSD) constitute rare autoimmune disorders of
the CNS that are primarily characterized by severe inflammation of the spinal cord and optic …

Multiple sclerosis (MS) is an autoimmune-mediated demyelinating disease of the central
nervous system. The main pathological features are inflammatory reaction, demyelination …

Background Interleukin 23 is a critical cytokine in the pathogenesis of multiple sclerosis. But
the local impact of interleukin 23 on the course of neuroinflammation is still not well defined …

Dysregulated B cell cytokine production contributes to pathogenesis of immune-mediated
diseases including multiple sclerosis (MS); however, the underlying mechanisms are poorly …

While it was long held that T cells were the primary mediators of multiple sclerosis (MS)
pathogenesis, the beneficial effects observed in response to treatment with Rituximab (RTX) …

B cells are key contributors to chronic autoimmune pathology in multiple sclerosis (MS).
Clonally related B cells exist in the cerebrospinal fluid (CSF), meninges, and CNS …

Autoimmune diseases of the central nervous system (CNS) such as multiple sclerosis (MS)
are only partially represented in current experimental models and the development of …

The discovery of an active lymphatic system in the meninges (dura mater) has opened up a
wide range of possibilities for the role of CNS immunoglobulins in brain development in …