Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two diseases
that form a broad neurodegenerative continuum. Considerable effort has been made to …

The global pandemic of sarcopenia, skeletal muscle loss and weakness, which prevails in
up to 50% of older adults is increasing worldwide due to the expansion of aging populations …

Synaptic loss is a pathological feature of all neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of …

The efficient study of human disease requires the proper tools, one of the most crucial of
which is an accurate animal model that faithfully recapitulates the human condition. The …

Expansion of the hexanucleotide repeat GGGGCC in the C9orf72 gene is the most common
genetic factor in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) …

Neurodegenerative diseases are prominent causes of pain, suffering, and death worldwide.
Traditional approaches modelling neurodegenerative diseases are deficient, and therefore …

Brown and beige adipocytes dissipate energy in a nonshivering thermogenesis manner,
exerting beneficial effects on metabolic homeostasis. CHCHD10 is a nuclear-encoded …

Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and Coiled-coil-helix-
coiled-coil-helix domain containing 10 (CHCHD10) are mitochondrial proteins that are …

The tremendously rising numbers of aged populations are associated with a heightened risk
for motor and functional declines. Sarcopenia is an active age-related process that involves …

Sarcopenia is a systemic skeletal muscle disease characterized by a decline in skeletal
muscle mass and function. Originally defined as an age‐associated condition, sarcopenia …