Effects of aging on the male reproductive system
The study aims to discuss the effects of aging on the male reproductive system. A systematic
review was performed using PubMed from 1980 to 2014. Aging is a natural process …
review was performed using PubMed from 1980 to 2014. Aging is a natural process …
[HTML][HTML] The molecular and cellular origin of human prostate cancer
JR Packer, NJ Maitland - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
Prostate cancer is the most commonly diagnosed male malignancy. Despite compelling
epidemiology, there are no definitive aetiological clues linking development to frequency …
epidemiology, there are no definitive aetiological clues linking development to frequency …
[HTML][HTML] The evolutionary history of 2,658 cancers
Cancer develops through a process of somatic evolution,. Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …
[HTML][HTML] Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today. Here
we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate …
we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate …
[HTML][HTML] MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets
Abstract c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression.
Although MYC is overexpressed in both early and metastatic disease and associated with …
Although MYC is overexpressed in both early and metastatic disease and associated with …
Integrative molecular concept modeling of prostate cancer progression
SA Tomlins, R Mehra, DR Rhodes, X Cao, L Wang… - Nature …, 2007 - nature.com
Despite efforts to profile prostate cancer, the genetic alterations and biological processes
that correlate with the observed histological progression are unclear. Using laser-capture …
that correlate with the observed histological progression are unclear. Using laser-capture …
Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a …
S Bettuzzi, M Brausi, F Rizzi, G Castagnetti… - Cancer research, 2006 - AACR
Green tea catechins (GTCs) proved to be effective in inhibiting cancer growth in several
experimental models. Recent studies showed that 30% of men with high-grade prostate …
experimental models. Recent studies showed that 30% of men with high-grade prostate …
[HTML][HTML] High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
Systemic metabolic alterations associated with increased consumption of saturated fat and
obesity are linked with increased risk of prostate cancer progression and mortality, but the …
obesity are linked with increased risk of prostate cancer progression and mortality, but the …
Multifocal prostate cancer: biologic, prognostic, and therapeutic implications
M Andreoiu, L Cheng - Human pathology, 2010 - Elsevier
Prostatic adenocarcinoma is the most common cancer diagnosed in men and is often
multifocal. Ongoing controversy exists about the most appropriate system of tumor …
multifocal. Ongoing controversy exists about the most appropriate system of tumor …
Prostate needle biopsies containing prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma: implications for patient care
JI Epstein, M Herawi - The Journal of urology, 2006 - Elsevier
PURPOSE: We identified information critical for patient treatment on prostate needle
biopsies diagnosed with prostatic intraepithelial neoplasia or atypical foci suspicious for …
biopsies diagnosed with prostatic intraepithelial neoplasia or atypical foci suspicious for …