Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

Abstract The mTOR complex 1 (mTORC1) kinase nucleates a pathway that promotes cell
growth and proliferation and is the target of rapamycin, a drug with many clinical uses …

The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the
TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely …

Protein synthesis is principally regulated at the initiation stage (rather than during elongation
or termination), allowing rapid, reversible and spatial control of gene expression. Progress …

The Ser-Thr kinase mammalian target of rapamycin (mTOR) controls cell growth and
metabolism by stimulating glycolysis and synthesis of proteins and lipids. To further …

The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …

The mammalian target of rapamycin (mTOR) kinase forms two multiprotein complexes,
mTORC1 and mTORC2, which regulate cell growth, cell survival, and autophagy. Allosteric …

The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of protein
synthesis. The best studied targets of mTORC1 in translation are the eukaryotic initiation …

Since the discovery of the phosphorylation of the 40S ribosomal protein S6 (rpS6) about four
decades ago, much effort has been made to uncover the molecular mechanisms underlying …