The complement system consists of effector proteins, regulators, and receptors that
participate in host defense against pathogens. Activation of the complement system, via the …

The complement system is an ancient and evolutionary conserved element of the innate
immune mechanism. It comprises of more than 20 serum proteins most of which are …

Background Atypical hemolytic–uremic syndrome is a genetic, life-threatening, chronic
disease of complement-mediated thrombotic microangiopathy. Plasma exchange or infusion …

Neutrophils deposit antimicrobial proteins, such as myeloperoxidase and proteases on
chromatin, which they release as neutrophil extracellular traps (NETs). Neutrophils also …

Background Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy
characterized by hemolysis, platelet consumption, and renal injury. Eculizumab, a mAb that …

Background. Atypical haemolytic uraemic syndrome (aHUS) is a rare, life-threatening
disorder for which eculizumab is the only approved treatment. Life-long treatment is …

Central to the pathogenesis of atypical haemolytic uraemic syndrome (aHUS) is over-
activation of the alternative pathway of complement. Inherited defects in complement genes …

Elevated numbers of activated platelets circulate in patients with chronic inflammatory
diseases, including atherosclerosis and coronary disease. Activated platelets can activate …

The plasma protein properdin is the only known positive regulator of complement activation.
Although regarded as an initiator of the alternative pathway of complement activation at the …

The complement system is an essential part of the innate immune system by acting as a first
line of defense which is stabilized by properdin, the sole known positive regulator of the …