The medical history of cancer began millennia ago. Historical findings of patients with
cancer date back to ancient Egyptian and Greek civilizations, where this disease was …

Gallbladder cancer (GBC) is rare, but is the most malignant type of biliary tract tumor.
Unfortunately, only a small population of cancer patients is acceptable for the surgical …

Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard
of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year …

Antiangiogenic drugs targeting the VEGF pathway have slowed metastatic disease
progression in some patients, leading to progression-free survival (PFS) and overall survival …

Tumor metastasis is driven not only by the accumulation of intrinsic alterations in malignant
cells, but also by the interactions of cancer cells with various stromal cell components of the …

Emerging evidence indicates that angiogenesis and immunosuppression frequently occur
simultaneously in response to diverse stimuli. Here, we describe a fundamental biological …

Solid tumors require blood vessels for growth and dissemination, and lymphatic vessels as
additional conduits for metastatic spread. The identification of growth factor receptor …

Vascular endothelial growth factor-A (VEGF), a potent angiogenic factor, is also implicated in
self-renewal in several normal tissue types. VEGF has been shown to drive malignant stem …

Addition of multiple molecularly targeted agents to the existing armamentarium of
chemotherapeutics and radiotherapies represents a significant advance in the management …