Purpose: The aim of the study was to investigate the vascular and stromal architecture of
preclinical tumor models and patient tumor specimens from malignancies with known …

Tumor angiogenesis is a degenerate process regulated by a complex network of
proangiogenic factors. Existing antiangiogenic drugs used in clinic are characterized by …

Protein and lipid kinases fulfill essential roles in many signaling pathways that regulate
normal cell functions. Deregulation of these kinase activities lead to a variety of pathologies …

Angiogenesis, the formation of new blood vessels, is an essential process for tumour
progression and is an area of significant therapeutic interest. Different in vitro systems and …

Importance of the field: Sorafenib is an oral receptor tyrosine kinase inhibitor that inhibits Raf
serine/threonine kinases and receptor tyrosine kinases (vascular endothelial growth factor …

Despite the clinical implication and high incidence of bone and spinal metastases, the
molecular mechanisms behind prostate cancer metastasis to bone and spine are not well …

Apatinib is a new oral antiangiogenic molecule that inhibits vascular endothelial growth
factor receptor-2. The present study aimed to determine the metabolism, pharmacokinetics …

Tumorigenesis is a complex multistep process involving not only genetic and epigenetic
changes in the tumor cell but also selective supportive conditions of the deregulated tumor …

This review aims to summarize the methods that have been used till today, highlight
methods that are currently being developed, and predict the future roadmap for anticancer …

Solid tumours initiate angiogenesis to support their growth by producing growth factors such
as VEGF. Depriving the tumour of the excessive vessels that support its growth became the …