Vitiligo is characterized by progressive loss of skin pigmentation. The search for aetiologic
factors has led to the biochemical, the neurologic and the autoimmune theory. The …

Traditional linkage analysis and genome-wide association studies have identified HLA and
a number of non-HLA genes as genetic factors for islet autoimmunity (IA) and type 1 …

Immune evasion is a critical step of cancer progression that remains a major obstacle for
current T cell–based immunotherapies. Hence, we investigated whether it is possible to …

Although light skin types are associated with increased skin cancer risk, a lower incidence of
both melanoma and nonmelanoma skin cancer (NMSC) has been reported in patients with …

Vitiligo is an acquired pigmentary disorder afflicting 0.5-2% of the world population for both
sexes and all races with a capricious and unpredictable course. It has a complex etiology …

Multiple factors are involved in the process leading to melanocyte loss in vitiligo including
environmental triggers, genetic polymorphisms, metabolic alterations, and autoimmunity …

BACKGROUND: Vitiligo is a common cutaneous disorder of the skin and hair caused by a
systemic depigmentation disorder that affects 1% of the population or less due to its onset in …

Vitiligo is an autoimmune disease in which melanocyte destruction causes skin
depigmentation, with 49 loci known from previous GWAS. Aiming to define vitiligo subtypes …

Vitiligo is impacted by environmental triggers. We studied the contribution of the microbiome
in FH mice, in which depigmentation is mediated by tyrosinase-reactive T cells. The mice …

Gene therapy is one of the most advanced therapies in current medicine. In particular,
interference RNA-based therapy by small interfering RNA (siRNA) has gained attention in …