• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The discovery of thousands of noncoding RNAs (ncRNAs) has expanded our view on
mammalian genomes and transcriptomes, as well as their organization and regulation …

Background Cardiac muscle hypercontractility is a key pathophysiological abnormality in
hypertrophic cardiomyopathy, and a major determinant of dynamic left ventricular outflow …

Abstract Background EXPLORER-HCM (Clinical Study to Evaluate Mavacamten [MYK-461]
in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy) demonstrated that …

Practical relevance: Hypertrophic cardiomyopathy (HCM) is the most common form of feline
cardiomyopathy observed clinically and may affect up to approximately 15% of the domestic …

The definition and classification of cardiomyopathy have evolved considerably in recent
years. Cardiomyopathy can be separated into primary (genetic, mixed, or acquired) and …

Hypertrophic cardiomyopathy (HCM), the most common inherited heart disease, is still
orphan of a specific drug treatment. The erroneous consideration of HCM as a rare disease …

Background The late sodium current inhibitor ranolazine reverses the main
electrophysiological and mechanical abnormalities of human hypertrophic cardiomyopathy …

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder,
affecting 1 in 500 individuals worldwide. Existing epidemiological studies might have …

Background: Over the last 50 years, the epidemiology of hypertrophic cardiomyopathy
(HCM) has changed because of increased awareness and availability of advanced …