Colorectal cancer is a leading cause of cancer related mortality in the Western world. In
recent years, combination 5-fluorouracil based adjuvant chemotherapy as first line treatment …

Microsatellite instability is a well‐recognised phenomenon. Ten to 15% of sporadic
colorectal cancers with a high level of MSI form a well defined group with distinct …

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer
predisposition syndrome caused by germ-line mutations in DNA mismatch repair genes. It is …

BACKGROUND The presence of high level DNA microsatellite instability (MSI-H) in
colorectal cancer is associated with an improved prognosis, as is the presence of tumour …

The significance of low-level DNA microsatellite instability (MSI-L) is not well understood. K-
ras mutation is associated with MSI-L colorectal cancer and with the silencing of the DNA …

AIM Colorectal cancer has been described in association with hyperplastic polyposis but the
mechanism underlying this observation is unknown. The aim of this study was to …

BACKGROUND: 10% of sporadic colorectal cancers are characterised by a low level of
microsatellite instability (MSI-L). These are not thought to differ substantially from …

Background Colorectal tumors caused by failure of the DNA mismatch repair system
commonly show microsatellite instability. Our goals were to compare the performance of two …

Twelve to 16% of colorectal cancers (CRCs) display a high degree of microsatellite
instability (MSI-H), whereas most are believed to be microsatellite stable (MSS). The …

Hyperplastic polyposis is a loosely defined syndrome initially thought not to confer a
clinically important predisposition to colorectal cancer. The aim of the current study was to …