To clarify the biological impact and molecular pathogenesis of cellular phenotype in
differentiated-type gastric cancers (DGCs), we investigated cell kinetics and genetic …

Genomic instability at simple repeated sequences, termed microsatellite instability (MSI),
plays an important role in the analysis of sporadic and hereditary colon cancers. In …

Loss of heterozygosity occurs frequently on the short arm of chromosome 8 in many
neoplasms, including colorectal and ovarian cancer. Monochromosome transfer …

Senescence, a state of cell cycle arrest, has been regarded as an intrinsic barrier to
malignance. Although being repressed in most immortal tumors, the genetic program of …

Increasing evidence suggests that human tumors sequentially accumulate multiple
mutations that cannot be explained by the low rates of spontaneous mutations in normal …

Aims—Microsatellite instability (MSI) was first observed in hereditary non-polyposis
colorectal carcinoma (HNPCC) and was subsequently seen in non-familial colorectal …

Microsatellite instability (MSI) is a distinct tumour phenotype that is associated with
alterations of DNA mismatch repair and is being increasingly reported in a number of …

Abstract Cytochrome P450 1B1 (CYP1B1) is a phase I xenobiotic-metabolizing enzyme
(XME) that is overexpressed in colorectal cancer (CRC) tissue, but the prognosis value of …

Abstract Background and Objectives Deregulation of apoptosis related genes may be
associated with poor outcome in cancer. Aim of the present study was to investigate the …

The molecular genetics of colorectal cancer is presented in an order that ascends from the
basic to the applied: molecular mechanisms, morphogenesis, classification and diagnosis …