Adjuvant physiochemistry and advanced nanotechnology for vaccine development

H Ren, W Jia, Y Xie, M Yu, Y Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

[HTML][HTML] Immune checkpoint inhibitors for vaccine improvements: current status and new approaches

A Batista-Duharte, F Hassouneh, P Alvarez-Heredia… - Pharmaceutics, 2022 - mdpi.com
In recent years, the use of immune checkpoint inhibitors (ICIs) in combination with approved
or experimental vaccines has proven to be a promising approach to improve vaccine …

[HTML][HTML] Polypharmacological cell-penetrating peptides from venomous marine animals based on immunomodulating, antimicrobial, and anticancer properties

S Hemmati, H Rasekhi Kazerooni - Marine Drugs, 2022 - mdpi.com
Complex pathological diseases, such as cancer, infection, and Alzheimer's, need to be
targeted by multipronged curative. Various omics technologies, with a high rate of data …

Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity

BH Pogostin, HY Marina, AR Azares, EM Euliano… - Biomaterials …, 2022 - pubs.rsc.org
Adjuvants play a critical role in enhancing vaccine efficacy; however, there is a need to
develop new immunomodulatory compounds to address emerging pathogens and to …

Dynamic imine bonding facilitates mannan release from a nanofibrous peptide hydrogel

BH Pogostin, G Saenz, CC Cole, EM Euliano… - Bioconjugate …, 2022 - ACS Publications
Recently, there has been increased interest in using mannan as an immunomodulatory
bioconjugate. Despite notable immunological and functional differences between the …

[HTML][HTML] Adjuvants approved for human use: What do we know and what do we need to know for designing good adjuvants?

C Reyes, MA Patarroyo - European Journal of Pharmacology, 2023 - Elsevier
Adjuvants represent one of the most significant biotechnological solutions regarding vaccine
development, thereby broadening the amount of candidates which can now be used and …

[HTML][HTML] A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via α-tocopherol component

Y Yoshioka, K Kobiyama, T Hayashi, M Onishi… - Frontiers in …, 2023 - frontiersin.org
Background Adjuvants are chemical or biological materials that enhance the efficacy of
vaccines. A-910823 is a squalene-based emulsion adjuvant used for S-268019-b, a novel …

PRR-HyPred: A two-layer hybrid framework to predict pattern recognition receptors and their families by employing sequence encoded optimal features

A Firoz, A Malik, HM Ali, Y Akhter, B Manavalan… - International Journal of …, 2023 - Elsevier
Pattern recognition receptors (PRRs) recognize distinct features on the surface of pathogens
or damaged cells and play key roles in the innate immune system. PRRs are divided into …

[HTML][HTML] Emerging Field-Effect Transistor Biosensors for Life Science Applications

A Panahi, E Ghafar-Zadeh - Bioengineering, 2023 - mdpi.com
Field-effect transistors (FETs) have gained significant interest and hold great potential as
groundbreaking sensing technology in the fields of biosensing and life science research …

[HTML][HTML] TLR9 and STING agonists cooperatively boost the immune response to SARS-CoV-2 RBD vaccine through an increased germinal center B cell response and …

JX Yang, JC Tseng, CF Tien, CY Lee… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Vaccines are a powerful medical intervention for preventing epidemic diseases. Efficient
inactivated or protein vaccines typically rely on an effective adjuvant to elicit an immune …