Macrophages exposed to inflammatory stimuli including LPS undergo metabolic
reprogramming to facilitate macrophage effector function. This metabolic reprogramming …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Flavonoids display a broad range of health-promoting bioactivities. Among these, their
capacity to act as antioxidants has remained most prominent. The canonical reactive oxygen …

The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the
expression of antioxidant and detoxification genes. Gene knockout approaches have …

Numerous microorganisms colonize the human gastrointestinal tract playing pivotal roles in
relation to digestion and absorption of dietary components. They biotransform food …

The objective of this study was to investigate the antioxidant properties of cottonseed
peptides. Results indicated that cottonseed peptides prepared by enzymatic hydrolysis and …

Polyphenols are natural organic compounds produced by plants, acting as antioxidants by
reacting with ROS. These compounds are widely consumed in daily diet and many studies …

Abstract Alzheimer's disease (AD), characterized by the accumulation of protein aggregates
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …

Although cisplatin is an effective anticancer drug, its clinical application is limited due to
various side effects, especially nephrotoxicity. In this study, we investigated the protective …

Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid
peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight …