Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target

OA Sukocheva, H Furuya, ML Ng, M Friedemann… - Pharmacology & …, 2020 - Elsevier
Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …

Targeting the sphingosine kinase/sphingosine-1-phosphate signaling axis in drug discovery for cancer therapy

P Gupta, A Taiyab, A Hussain, MF Alajmi, A Islam… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is the prime cause of death globally. The altered stimulation of
signaling pathways controlled by human kinases has often been observed in various human …

The influence of different polymer types of microplastics on adsorption, accumulation, and toxicity of triclosan in zebrafish

C Sheng, S Zhang, Y Zhang - Journal of hazardous materials, 2021 - Elsevier
Although the combined effects of microplastics (MPs) and other organic pollutants have
raised increasing attention, the impacts of polymer types on the biological effects (eg …

Sphingosine‐1‐phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy

H Kawai, Y Osawa, M Matsuda, T Tsunoda… - …, 2022 - Wiley Online Library
Abstract Background and Aims Chronic liver congestion reflecting right‐sided heart failure
(RHF), Budd‐Chiari syndrome, or Fontan‐associated liver disease (FALD) is involved in …

Circulating sphingolipids in insulin resistance, diabetes and associated complications

SM Hammad, MF Lopes-Virella - International Journal of Molecular …, 2023 - mdpi.com
Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …

Hydrogen sulfide as a novel regulatory factor in liver health and disease

DD Wu, DY Wang, HM Li, JC Guo… - … medicine and cellular …, 2019 - Wiley Online Library
Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been recognized as
a toxic gas and environment pollutant. However, increasing evidence suggests that H2S …

The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target

SS Alkafaas, MI Elsalahaty, DF Ismail… - Cancer Cell …, 2024 - Springer
Cancer chemoresistance is a problematic dilemma that significantly restrains numerous
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …

Predictive metabolomic signatures for safety assessment of metal oxide nanoparticles

L Cui, X Wang, B Sun, T Xia, S Hu - Acs Nano, 2019 - ACS Publications
The widespread use of metal oxide nanoparticles (MOx NPs) poses a risk of exposure that
may lead to adverse health effects on humans. Even though a number of toxicological …

Bile acids and sphingolipids in non-alcoholic fatty liver disease

KG Jackson, GW Way, H Zhou - Chinese Medical Journal, 2022 - mednexus.org
Non-alcoholic fatty liver disease (NAFLD) is one of the fastest-growing diseases, and its
global prevalence is estimated to increase> 50% by 2030. NAFLD is comorbid with …

Female oncofertility: current understandings, therapeutic approaches, controversies, and future perspectives

KCT Vo, K Kawamura - Journal of Clinical Medicine, 2021 - mdpi.com
Recent advances in early detection and oncological therapies have ameliorated the survival
rate of young cancer patients. Yet, ovarian impairment induced by chemotherapy and …