Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target
Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …
Targeting the sphingosine kinase/sphingosine-1-phosphate signaling axis in drug discovery for cancer therapy
Simple Summary Cancer is the prime cause of death globally. The altered stimulation of
signaling pathways controlled by human kinases has often been observed in various human …
signaling pathways controlled by human kinases has often been observed in various human …
The influence of different polymer types of microplastics on adsorption, accumulation, and toxicity of triclosan in zebrafish
C Sheng, S Zhang, Y Zhang - Journal of hazardous materials, 2021 - Elsevier
Although the combined effects of microplastics (MPs) and other organic pollutants have
raised increasing attention, the impacts of polymer types on the biological effects (eg …
raised increasing attention, the impacts of polymer types on the biological effects (eg …
Sphingosine‐1‐phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy
H Kawai, Y Osawa, M Matsuda, T Tsunoda… - …, 2022 - Wiley Online Library
Abstract Background and Aims Chronic liver congestion reflecting right‐sided heart failure
(RHF), Budd‐Chiari syndrome, or Fontan‐associated liver disease (FALD) is involved in …
(RHF), Budd‐Chiari syndrome, or Fontan‐associated liver disease (FALD) is involved in …
Circulating sphingolipids in insulin resistance, diabetes and associated complications
SM Hammad, MF Lopes-Virella - International Journal of Molecular …, 2023 - mdpi.com
Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …
diabetes, as well as in the development of both micro-and macro-vascular complications …
Hydrogen sulfide as a novel regulatory factor in liver health and disease
DD Wu, DY Wang, HM Li, JC Guo… - … medicine and cellular …, 2019 - Wiley Online Library
Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been recognized as
a toxic gas and environment pollutant. However, increasing evidence suggests that H2S …
a toxic gas and environment pollutant. However, increasing evidence suggests that H2S …
The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target
SS Alkafaas, MI Elsalahaty, DF Ismail… - Cancer Cell …, 2024 - Springer
Cancer chemoresistance is a problematic dilemma that significantly restrains numerous
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …
Predictive metabolomic signatures for safety assessment of metal oxide nanoparticles
The widespread use of metal oxide nanoparticles (MOx NPs) poses a risk of exposure that
may lead to adverse health effects on humans. Even though a number of toxicological …
may lead to adverse health effects on humans. Even though a number of toxicological …
Bile acids and sphingolipids in non-alcoholic fatty liver disease
KG Jackson, GW Way, H Zhou - Chinese Medical Journal, 2022 - mednexus.org
Non-alcoholic fatty liver disease (NAFLD) is one of the fastest-growing diseases, and its
global prevalence is estimated to increase> 50% by 2030. NAFLD is comorbid with …
global prevalence is estimated to increase> 50% by 2030. NAFLD is comorbid with …
Female oncofertility: current understandings, therapeutic approaches, controversies, and future perspectives
KCT Vo, K Kawamura - Journal of Clinical Medicine, 2021 - mdpi.com
Recent advances in early detection and oncological therapies have ameliorated the survival
rate of young cancer patients. Yet, ovarian impairment induced by chemotherapy and …
rate of young cancer patients. Yet, ovarian impairment induced by chemotherapy and …