CD47: role in the immune system and application to cancer therapy

SMG Hayat, V Bianconi, M Pirro, MR Jaafari… - Cellular Oncology, 2020 - Springer
Background CD47 is a widely expressed cellular receptor well known for its
immunoregulatory functions. By interacting with its ligands, including thrombospondin-1 …

Role of CD47 in hematological malignancies

E Eladl, R Tremblay-LeMay, N Rastgoo… - Journal of hematology & …, 2020 - Springer
CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by
nearly all cells of the body. It plays an integral role in various immune responses as well as …

Silencing of microRNA families by seed-targeting tiny LNAs

S Obad, CO dos Santos, A Petri, M Heidenblad… - Nature …, 2011 - nature.com
The challenge of understanding the widespread biological roles of animal microRNAs
(miRNAs) has prompted the development of genetic and functional genomics technologies …

CD47: a cell surface glycoprotein which regulates multiple functions of hematopoietic cells in health and disease

PA Oldenborg - International Scholarly Research Notices, 2013 - Wiley Online Library
Interactions between cells and their surroundings are important for proper function and
homeostasis in a multicellular organism. These interactions can either be established …

CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest

E Sick, A Jeanne, C Schneider… - British journal of …, 2012 - Wiley Online Library
CD47 is a ubiquitous 50 kDa five‐spanning membrane receptor that belongs to the
immunoglobulin superfamily. This receptor, also known as integrin‐associated protein …

Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer

M Alhosin, Z Omran, MA Zamzami, AL Al-Malki… - Journal of Experimental …, 2016 - Springer
Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and
histone changes is a main hallmark of cancer. U biquitin-like with PHD and R ING F inger …

Preclinical and clinical development of therapeutic antibodies targeting functions of CD47 in the tumor microenvironment

S Kaur, KV Cicalese, R Banerjee… - Antibody …, 2020 - academic.oup.com
ABSTRACT CD47 is a ubiquitously expressed cell surface glycoprotein that functions as a
signaling receptor for thrombospondin-1 and as the counter-receptor for signal regulatory …

Checkpoint CD47 function on tumor metastasis and immune therapy

S Lian, X Xie, Y Lu, L Jia - OncoTargets and therapy, 2019 - Taylor & Francis
The success of cancer immunotherapy on recognition checkpoints for killing cancer cells
has raised a great interest of scientists in understanding new and old methods of …

[HTML][HTML] Crosstalk between colon cancer cells and macrophages via inflammatory mediators and CD47 promotes tumour cell migration

Y Zhang, W Sime, M Juhas, A Sjölander - European journal of cancer, 2013 - Elsevier
Tumour-associated macrophages (TAMs) of the M2 phenotype are present in the stroma of
many tumours and are frequently associated with the progression of several types of cancer …

Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK–MMP-9 pathway

A Radziwon-Balicka, MJ Santos-Martinez… - …, 2014 - academic.oup.com
Platelets have been implicated in colon cancer metastasis and prognosis but the underlying
molecular mechanisms remain unclear. We evaluated the role of the different mitogen …