Background The placebo effect often undermines efforts to determine treatment
effectiveness in clinical trials. A significant placebo response occurs in alcohol trials, but it is …

The treatment of alcohol dependence mainly consists of psychological, social, and
pharmacotherapeutic interventions aiming to reduce physical withdrawal, craving, and …

Polysubstance abuse of alcohol and nicotine has been overlooked in our understanding of
the neurobiology of addiction and especially in the development of novel therapeutics for its …

By updating John Littleton's work published 15 years ago this review summarizes recent
work on pharmacodynamic aspects of acamprosate and the perspective for future …

Harmful alcohol use is a risk factor in more than 60 diseases and injuries resulting in
approximately 2.5 million deaths per year worldwide. In the United States (US) and Europe …

Chronic alcohol exposure causes marked changes in reinforcement mechanisms and
motivational state that are thought to contribute to the development of cravings and relapse …

Both human and animal studies indicate that the dentate gyrus (DG) of the hippocampus is
highly exploited by drug and alcohol abuse. Yet, it is poorly understood how DG dysfunction …

Aim s: To compare the long-term effectiveness of acamprosate (ACP) and disulfiram (DSF)
in the treatment of alcohol dependence and their effectiveness in regard to patient …

Randomized controlled trials (RCTs) evaluating medications for alcohol use disorder (AUD)
often examine heterogeneity of treatment effects through subgroup analyses that contrast …

The present study examined the effects of the acute intraperitoneal (ip) administration of the
selective dopamine (DA) D3 receptor antagonist SB‐277011A (10, 20 or 30 mg/kg ip) on the …