The embryonic surface ectoderm gives rise to the epidermis and ectodermal appendages
including hair follicles, teeth, scales, feathers, and mammary, sweat, and salivary glands …

Mammalian tooth development is a precise and complicated procedure. Several signaling
pathways, such as nuclear factor (NF)–κB and WNT, are key regulators of tooth …

Tooth number abnormality is one of the most common dental developmental diseases,
which includes both tooth agenesis and supernumerary teeth. Tooth development is …

Wnt signaling plays an essential role in the dental epithelium and mesenchyme during tooth
morphogenesis. However, it remains unclear if Wnt ligands, produced from dental …

Epidermal stratification of the mammalian skin requires proliferative basal progenitors to
generate intermediate cells that separate from the basal layer and are replaced by post …

Appropriate tooth root formation and tooth eruption are critical for achieving and maintaining
good oral health and quality of life. Tooth eruption is the process through which teeth …

Despite much progress in understanding the genetics of syndromic tooth agenesis (TA), the
causes of the most common, isolated TA remain elusive. Recent studies have identified …

BMP and Wnt signaling pathways play a crucial role in organogenesis, including tooth
development. Despite extensive studies, the exact functions, as well as if and how these two …

Tooth agenesis is a common craniofacial abnormality in humans and represents failure to
develop 1 or more permanent teeth. Tooth agenesis is complex, and variations in about a …

Wnt signaling plays a central role in many processes during embryonic development and
adult homeostasis. At least 19 types of Wnt ligands, receptors, transducers, transcription …