Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with a
history of repetitive head impacts (RHI). CTE was described in boxers as early as the 1920s …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a
frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its …

Neurodegenerative diseases (NDDs) are characterized by selective dysfunction and loss of
neurons associated with pathologically altered proteins that deposit in the human brain but …

Abnormal filaments of known composition in neurons and glia define many sporadic and
hereditary human neurodegenerative diseases. The pathogenic significance of filamentous …

Highlights•Accelerated aging happens when biological age outpaces chronological age.•In
addiction the early-onset of comorbid diseases remains mostly undetected.•Oxidation …

Chronic exposure to addictive drugs in substance use disorders and stressors in mood
disorders render the brain more vulnerable to inflammation. Inflammation in the brain, or …

Deposition of amyloid-β (Aβ) in the brain parenchyma and vessels is one of the hallmarks of
Alzheimer disease (AD). Recent observations of Aβ deposition in iatrogenic Creutzfeldt …

In the 20th century, chronic traumatic encephalopathy (CTE) was conceptualized as a
neurological disorder affecting some active and retired boxers who had tremendous …

Parkinson's disease (PD) is a common neuro-degenerative disorder, and novel therapeutic
targets are required for the treatment of PD. Juglanin is a natural compound extracted from …