Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Prostate cancer (PC) is a leading cause of death in men. Inflammation is one of the initiating
processes whereby cells are trafficked into the tumor microenvironment by specific cytokines …

Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer
(PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic …

The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …

The tumor suppressor gene PTEN is one of the most often deleted genes in human prostate
cancer. Loss of PTEN is an important event in prostate carcinogenesis. Metabolic …

Abstract The phosphoinositide 3-kinase (PI3K) pathway integrates multifarious
environmental cues to regulate cell survival, growth, and metabolism. Hyperactivation of the …

Prostate cancer (PCa) is the most common cancer in men, and the global burden of the
disease is rising. The majority of PCa deaths are due to metastasis that are highly resistant …

Scope Resistance of castrate‐resistant prostate cancer (CRPC) to enzalutamide (Enz)
involves the expression of constitutively active androgen receptor splice variant (AR‐V7). In …

Most prostate cancer patients will progress to a castration-resistant state (CRPC) after
androgen ablation therapy and despite the development of new potent anti-androgens, like …

Prostate cancer (PCa) is the most commonly diagnosed malignancy and the second leading
cause of cancer-related death in American men. Androgen deprivation therapy (ADT) has …