Aflatoxins: History, significant milestones, recent data on their toxicity and ways to mitigation

D Pickova, V Ostry, J Toman, F Malir - Toxins, 2021 - mdpi.com
In the early 1960s the discovery of aflatoxins began when a total of 100,000 turkey poults
died by hitherto unknown turkey “X” disease in England. The disease was associated with …

[HTML][HTML] In vitro and in vivo evaluation of AFB1 and OTA-toxicity through immunofluorescence and flow cytometry techniques: A systematic review

M Frangiamone, A Cimbalo, M Alonso-Garrido… - Food and Chemical …, 2022 - Elsevier
Due to the globalization, mycotoxins have been considered a major risk to human health
being the main contaminants of foodstuffs. Among them, AFB1 and OTA are the most toxic …

Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway

SA Rajput, A Shaukat, K Wu, IR Rajput, DM Baloch… - Antioxidants, 2021 - mdpi.com
Aflatoxin B1 (AFB1), a threatening mycotoxin, usually provokes oxidative stress and causes
hepatotoxicity in animals and humans. Luteolin (LUTN), well-known as an active …

Cytotoxicity of mycotoxins and their combinations on different cell lines: a review

P Skrzydlewski, M Twarużek, J Grajewski - Toxins, 2022 - mdpi.com
Mycotoxins are secondary metabolites of molds and mainly produced by species of the
genera Aspergillus, Penicillium and Fusarium. They can be synthesized on the field, during …

Recent trends in fluorescent aptasensors for mycotoxin detection in food: Principles, constituted elements, types, and applications

X Yan, H Chen, G Du, Q Guo, Y Yuan, T Yue - Food Frontiers, 2022 - Wiley Online Library
Mycotoxins are the secondary metabolites of fungi in food and can be toxic to people.
Therefore, developing simple, sensitive, and specific detection methods to detect mycotoxins …

[HTML][HTML] Ginsenoside Rb1 prevents deoxynivalenol-induced immune injury via alleviating oxidative stress and apoptosis in mice

SA Rajput, A Shaukat, IR Rajput, AA Kamboh… - Ecotoxicology and …, 2021 - Elsevier
Deoxynivalenol (DON) is considered to be a grave threat to humans and animals.
Ginsenoside Rb1 (Rb1) has been reported for its antioxidant potential and medicinal …

[HTML][HTML] Dual effects of zearalenone on aflatoxin B1–induced liver and mammary gland toxicity in pregnant and lactating rats

K Wu, S Jia, D Xue, SA Rajput, M Liu, D Qi… - … and Environmental Safety, 2022 - Elsevier
Food and feed are frequently co-contaminated with aflatoxin B1 (AFB1) and zearalenone
(ZEN). This study investigated the effects of ZEN on the AFB1–induced liver and mammary …

Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS

A Gerdemann, B Cramer, GH Degen, J Veerkamp… - Archives of …, 2023 - Springer
Abstract Aflatoxin B1 (AFB1) is a highly hepatotoxic and carcinogenic mycotoxin produced
by Aspergillus species. The compound is mainly metabolized in the liver and its metabolism …

Role of epigenetics in mycotoxin toxicity: A review

L Li, Z He, Y Shi, H Sun, B Yuan, J Cai, J Chen… - Environmental …, 2023 - Elsevier
Mycotoxins can induce cell cycle disorders, cell proliferation, oxidative stress, and apoptosis
through pathways such as those associated with MAPK, JAK2/STAT3, and Bcl-w/caspase-3 …

The role of N6-methyladenosine methylation in environmental exposure-induced health damage

Y Feng, T Liu, S Xu, Y Ren, Y Ge, L Yin, Y Pu… - … Science and Pollution …, 2022 - Springer
The health risks caused by environmental pollution have long been of substantial concern.
With the development of epigenetics, a large number of studies have demonstrated that N6 …