To enable survival in adverse conditions, cancer cells undergo global metabolic
adaptations. The amino acid cysteine actively contributes to cancer metabolic remodelling …

Globally, more than 20% of women of reproductive age are currently estimated to be obese.
Children born to obese mothers are at higher risk of developing obesity, coronary heart …

Elevation in homocysteine (Hcy) level is associated with insulin resistance; however, the
causality between them and the underlying mechanism remain elusive. Here, we show that …

Gastric cancer (GC) presents high mortality worldwide because of delayed diagnosis.
Currently, exosome-based liquid biopsy has been applied in diagnosis and monitoring of …

The kidneys are a vital organ that is vulnerable to both acute kidney injury (AKI) and chronic
kidney disease (CKD) which can be caused by numerous risk factors such as ischemia …

Major Depressive Disorder (MDD) is a highly prevalent psychiatric disorder worldwide. It
causes individual suffering, loss of productivity, increased health care costs and high suicide …

Folic acid (FA)-induced acute kidney injury (AKI) is a widely used model for studies of the
renal damage and its progression to chronic state. However, the molecular mechanisms by …

Capecitabine is an oral prodrug of 5-fluorouracil (5-FU) and approved for treatment of
various malignancies. Hereditary genetic variants may affect a drug's pharmacokinetics or …

The process of DNA CpG methylation has been extensively investigated for over 50 years
and revealed associations between changing methylation status of CpG islands and gene …

Telomeres are nucleotide tandem repeats located at the tip of eukaryotic chromosomes that
maintain genomic integrity. The gradual shortening of telomeres leads to cellular …