Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Loss of the tumor suppressor phosphatase and tensin homologue deleted on chromosome
10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to …

Purpose: Antibodies against insulin-like growth factor (IGF) type 1 receptor have shown
meaningful but transient tumor responses in patients with rhabdomyosarcoma (RMS). The …

Simple Summary Prostate cancer (PCa) affects millions of men globally, and approximately
20% of PCa patients are found after they develop into a lethal metastatic or castration …

Background This multicentre, open-label, Phase Ib/II trial evaluated the insulin-like growth
factor (IGF) 1/2 neutralising antibody xentuzumab plus enzalutamide in metastatic castrate …

Background Prostate cancer is one of leading causes of cancer death among men
worldwide. Androgen deprivation therapy is a central part of the prostate cancer treatment …

Breast cancer (BC) and prostate cancer (PC) are at the top of the list when it comes to the
most common types of cancers worldwide. The phosphatidylinositol 3-kinase (PI3K)/protein …

Several studies have investigated the role of inflammation in promoting tumorigenesis and
cancer progression. Neoplastic as well as surrounding stromal and inflammatory cells …

In respect to the enhanced incidence rate of cancer worldwide, studies have focused on
cancer therapy using novel strategies. Chemotherapy is a common strategy in cancer …

Background Autophagy is a well-conserved catabolic process that plays a key role in cell
homeostasis. In the prostate, defective autophagy has been implicated in the genesis and …