Breaking genetic shackles: The advance of base editing in genetic disorder treatment

F Xu, C Zheng, W Xu, S Zhang, S Liu… - Frontiers in …, 2024 - frontiersin.org
The rapid evolution of gene editing technology has markedly improved the outlook for
treating genetic diseases. Base editing, recognized as an exceptionally precise genetic …

Exploiting protein domain modularity to enable synthetic control of engineered cells

Y Haikal, J Blazeck - Current Opinion in Biomedical Engineering, 2024 - Elsevier
The ability to precisely control cellular function in response to external stimuli can enhance
the function and safety of cell therapies. In this review, we will detail how the modularity of …

TF-High-Evolutionary: In Vivo Mutagenesis of Gene Regulatory Networks for the Study of the Genetics and Evolution of the Drosophila Regulatory Genome

XC Li, V Srinivasan, I Laiker, N Misunou… - Molecular Biology …, 2024 - academic.oup.com
Understanding the evolutionary potential of mutations in gene regulatory networks is
essential to furthering the study of evolution and development. However, in multicellular …

Optimized protoplast isolation and transfection with a breakpoint: accelerating Cas9/sgRNA cleavage efficiency validation in monocot and dicot

D Panda, S Karmakar, M Dash, SK Tripathy, P Das… - aBIOTECH, 2024 - Springer
The CRISPR-Cas genome editing tools are revolutionizing agriculture and basic biology
with their simplicity and precision ability to modify target genomic loci. Software-predicted …

CRISPR beyond: harnessing compact RNA-guided endonucleases for enhanced genome editing

F Wang, S Ma, S Zhang, Q Ji, C Hu - Science China Life Sciences, 2024 - Springer
The CRISPR-Cas system, an adaptive immunity system in prokaryotes designed to combat
phages and foreign nucleic acids, has evolved into a groundbreaking technology enabling …

CRISPR/Cas-mediated germplasm improvement and new strategies for crop protection

G Dong, Z Fan - Crop Health, 2024 - Springer
Global agriculture and food security are encountering unprecedented challenges from both
the ever-growing population and rapidly changing climate conditions. CRISPR/Cas …

Abscission in plants: from mechanism to applications

J Li, S Su - Advanced Biotechnology, 2024 - Springer
Abscission refers to the natural separation of plant structures from their parent plants,
regulated by external environmental signals or internal factors such as stress and aging. It is …

2023 年小麦新基因挖掘和遗传改良新技术研究回眸

叶兴国, 林志珊, 王轲, 唐华丽, 韩志阳 - 科技导报, 2024 - kjdb.org
2023 年小麦生物育种相关研究取得了重要进展: 挖掘了调控小麦高产, 抗病, 抗旱,
耐低温等性状相关的新基因, 创制了具有高产, 抗病, 优质等性状的新种质, 构建了大批量EMS …

Annual progress on new gene characterization and novel technology development for wheat genetic improvement in 2023

X YE, Z LIN, K WANG, H TANG, Z HAN - Science & Technology Review, 2024 - kjdb.org
In the past year, dramatic progress on wheat genetic improvement was achieved, including
the exploring of new genes related to high yield, disease resistance, and drought and low …