Stem cells are defined by their capabilities to self-renew and give rise to various types of
differentiated cells depending on their potency. They are classified as pluripotent …

Reprogramming, or generation of induced pluripotent stem (iPS) cells (functionally similar to
embryonic stem cells or ES cells) by the use of transcription factors (typically: Oct3/4, Sox2, c …

The cancer stem cell (CSC) hypothesis has gained significant recognition as a descriptor of
tumorigenesis. Additionally, tumor-associated macrophages (TAMs) are known to promote …

Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells
biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer …

Despite advances in the field of somatic cell reprogramming, an understanding and
exploration of the underlying mechanisms governing this process are only recently …

In 2006, the “wall came down” that limited the experimental conversion of differentiated cells
into the pluripotent state. In a landmark report, Shinya Yamanaka's group described that a …

Aims Thrombospondin-1 (TSP1) is a ligand for CD47 and TSP1−/− mice are protected from
pulmonary hypertension (PH). We hypothesized the TSP1–CD47 axis is upregulated in …

Mechanisms that direct reprogramming of differentiated somatic cells to induced pluripotent
stem cells (iPSCs), albeit incomplete in understanding, are highly conserved across all …

Induced pluripotent stem cells (iPSCs) have elicited excitement in both the scientific and
ethics communities for their potential to advance basic and translational research. They …

Epigenetic enzymes regulate higher-order chromatin architecture and cell-type specific
gene expression. The ATPase BRG1 and the SWI/SNF chromatin remodeling complex are …