Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Introduction Ferroptosis is an iron-dependent regulated necrosis and has been proven to
contribute to the progress of acute kidney injury (AKI). Quercetin (QCT), a natural flavonoid …

The kidney requires a large number of mitochondria to remove waste from the blood and
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …

Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …

Obesity has been recognized as a major risk factor for chronic kidney disease, but the
underlying mechanism remains elusive. Here, we investigated the mechanism whereby long …

Mitochondria are essential organelles in physiology and kidney diseases, because they
produce cellular energy required to perform their function. During mitochondrial metabolism …

Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …

Acute kidney injury (AKI) is a global public health concern associated with high morbidity
and mortality. Although advances in medical management have improved the in-hospital …