Fibroblasts are the major cell population of connective tissue, including the skin dermis, and
are best known for their function in depositing and remodelling the extracellular matrix …

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease of unknown
etiology with limited treatment options. It is characterized by repetitive injury to alveolar …

Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that
affects alveoli elasticity, which leading to higher rates of hospitalization and mortality …

Chronic Kidney Disease (CKD) is characterized by organ remodeling and fibrosis due to
failed wound repair after on-going or severe injury. Key to this process is the continued …

Cancers show a metabolic shift towards aerobic glycolysis. By “corrupting” their
microenvironment, carcinoma cells are able to obtain energy substrates to “fuel” their …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the normal alveolar network is
gradually replaced by fibrotic scars. Current evidence suggests that metabolic alterations …

Cancer metabolism is an extensively studied field since the discovery of the Warburg effect
about 100 years ago and continues to be increasingly intriguing and enigmatic so far. It has …

Background Fibroblasts have important roles in the synthesis and remodeling of
extracellular matrix (ECM) proteins during pulmonary fibrosis. However, the spatiotemporal …

Pulmonary fibrosis is a chronic and progressive lung disease characterized by the
accumulation of scar tissue in the lungs, which leads to impaired lung function and reduced …

Renal fibrosis contributes to progressive damage to renal structure and function. It is a
common pathological process as chronic kidney disease develops into kidney failure …