Cathepsin B gene knockout improves behavioral deficits and reduces pathology in models of neurologic disorders
G Hook, T Reinheckel, J Ni, Z Wu, M Kindy… - Pharmacological …, 2022 - ASPET
Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders
V Hook, M Yoon, C Mosier, G Ito, S Podvin… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Investigations of Alzheimer's disease (AD), traumatic brain injury (TBI), and related brain
disorders have provided extensive evidence for involvement of cathepsin B, a lysosomal …
disorders have provided extensive evidence for involvement of cathepsin B, a lysosomal …
Comprehensive evaluation of the 5XFAD mouse model for preclinical testing applications: a MODEL-AD study
The ability to investigate therapeutic interventions in animal models of neurodegenerative
diseases depends on extensive characterization of the model (s) being used. There are …
diseases depends on extensive characterization of the model (s) being used. There are …
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's …
We developed an endophenotype disease module-based methodology for Alzheimer's
disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier …
disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier …
Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier
SE Storck, S Meister, J Nahrath… - The Journal of …, 2016 - Am Soc Clin Investig
According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor–
related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to …
related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to …
[HTML][HTML] Identification of molecular signatures and pathways to identify novel therapeutic targets in Alzheimer's disease: Insights from a systems biomedicine …
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, there are …
accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, there are …
Visuo‐spatial learning and memory impairments in the 5xFAD mouse model of Alzheimer's disease: Effects of age, sex, albinism, and motor impairments
TP O'Leary, RE Brown - Genes, Brain and Behavior, 2022 - Wiley Online Library
The 5xFAD mouse model of Alzheimer's disease (AD) rapidly develops AD‐related neuro‐
behavioral pathology. Learning and memory impairments in 5xFAD mice, however, are not …
behavioral pathology. Learning and memory impairments in 5xFAD mice, however, are not …
Association of peripheral blood DNA methylation level with Alzheimer's disease progression
Background Identifying biomarkers associated with Alzheimer's disease (AD) progression
may enable patient enrichment and improve clinical trial designs. Epigenome-wide …
may enable patient enrichment and improve clinical trial designs. Epigenome-wide …
Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease
V Landel, K Baranger, I Virard, B Loriod… - Molecular …, 2014 - Springer
Background The 5XFAD early onset mouse model of Alzheimer's disease (AD) is gaining
momentum. Behavioral, electrophysiological and anatomical studies have identified age …
momentum. Behavioral, electrophysiological and anatomical studies have identified age …
Effects of long-term environmental enrichment on anxiety, memory, hippocampal plasticity and overall brain gene expression in C57BL6 mice
M Hüttenrauch, G Salinas, O Wirths - Frontiers in molecular …, 2016 - frontiersin.org
There is ample evidence that physical activity exerts positive effects on a variety of brain
functions by facilitating neuroprotective processes and influencing neuroplasticity …
functions by facilitating neuroprotective processes and influencing neuroplasticity …