Assays for noninvasive imaging of reporter gene expression
SS Gambhir, JR Barrio, HR Herschman… - Nuclear medicine and …, 1999 - Elsevier
Repeated, noninvasive imaging of reporter gene expression is emerging as a valuable tool
for monitoring the expression of genes in animals and humans. Monitoring of organ/cell …
for monitoring the expression of genes in animals and humans. Monitoring of organ/cell …
Monitoring gene therapy with reporter gene imaging
Rapid advances in imaging technologies and gene transfer strategies offer a great
opportunity to optimize clinical trials of human gene therapy. Reporter genes are emerging …
opportunity to optimize clinical trials of human gene therapy. Reporter genes are emerging …
Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography
We are developing quantitative assays to repeatedly and noninvasively image expression of
reporter genes in living animals, using positron emission tomography (PET). We synthesized …
reporter genes in living animals, using positron emission tomography (PET). We synthesized …
Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression
The efficacy of 3 radiolabeled probes of current interest for imaging herpes simplex virus
type 1 thymidine kinase (HSV1-tk) expression in vivo with PET, including 124I-or 131I …
type 1 thymidine kinase (HSV1-tk) expression in vivo with PET, including 124I-or 131I …
PET imaging of transgene expression
A vital step in transgenic animal study and gene therapy is the ability to assay the extent of
transgene expression. Unfortunately, classic methods of assaying transgene expression …
transgene expression. Unfortunately, classic methods of assaying transgene expression …
Imaging gene expression: principles and assays
SS Gambhir, JR Barrio, HR Herschman… - Journal of Nuclear …, 1999 - Elsevier
Nuclear imaging has a rich history rooted in the development of tracers and imaging assays
for, the improved diagnosis and management of many different diseases. The last decade …
for, the improved diagnosis and management of many different diseases. The last decade …
Synthesis of 8-[18F] fluoroguanine derivatives: in vivo probes for imaging gene expression with positron emission tomography
M Namavari, JR Barrio, T Toyokuni, SS Gambhir… - Nuclear medicine and …, 2000 - Elsevier
A new method for the preparation of 8-[18F] fluoroguanine derivatives based on a direct
radiofluorination reaction has been developed. The radiofluorination of ganciclovir (1a) with …
radiofluorination reaction has been developed. The radiofluorination of ganciclovir (1a) with …
5-Alkynyl Analogs of Arabinouridine and 2 '-Deoxyuridine: Cytostatic Activity against Herpes Simplex Virus and Varicella-Zoster Thymidine Kinase Gene-Transfected …
WA Cristofoli, LI Wiebe, E De Clercq… - Journal of medicinal …, 2007 - ACS Publications
A group of arabinouridines (TMSEAU, EAU, IEAU-TA) and 2 '-deoxyuridines (TMSEDU,
EDU, IEDU) having a variety of substituents at the uracil C-5 position (trimethylsilylethynyl …
EDU, IEDU) having a variety of substituents at the uracil C-5 position (trimethylsilylethynyl …
Feasibility of sodium/iodide symporter gene as a new imaging reporter gene: comparison with HSV1-tk
Positron emission tomography (PET) imaging reporter genes, such as HSV1-tk and D 2
receptor genes, make it possible to visualise gene expression non-invasively and …
receptor genes, make it possible to visualise gene expression non-invasively and …
Hydrogermylation of 5-ethynyluracil nucleosides: formation of 5-(2-germylvinyl) uracil and 5-(2-germylacetyl) uracil nucleosides
A stereoselective radical-mediated hydrogermylation of the protected 5-ethynyluracil
nucleosides with trialkyl-, triaryl,-or tris (trimethylsilyl) germanes gave (Z)-5-(2-germylvinyl) …
nucleosides with trialkyl-, triaryl,-or tris (trimethylsilyl) germanes gave (Z)-5-(2-germylvinyl) …