The mechanisms by which malignant tumors leave the primary tumor site, invade
lymphatics, and metastasize to regional lymph nodes (RLNs) are complex and interrelated …

Lymphatic vessel endothelial hyaluronan receptor (LYVE)-1 is thought to be restricted to
lymph vessels and has been used as such to show that tumor lymphangiogenesis occurs on …

Lymphatic metastasis is facilitated by lymphangiogenic growth factors VEGF-C and VEGF-D
that are secreted by some primary tumors. We identified regulation of PGDH, the key …

Blood and lymphatic vessels develop in a parallel, but independent manner, and together
form the circulatory system allowing the passage of fluid and delivering molecules within the …

Background: Vascular endothelial growth factor C (VEGF-C) stimulates tumor
lymphangiogenesis (ie, formation of lymphatic vessels) and metastasis to regional lymph …

The partition of fluid between the vascular and interstitial compartments is regulated by
forces (hydrostatic and oncotic) operating across the microvascular walls and the surface …

How tumors access and spread via the lymphatics is not understood. Although it is clear that
dissemination via the blood system involves hemangiogenesis, it is uncertain whether …

Previous research into hyaluronan (HA) has focused on the role of this abundant tissue
glycosaminoglycan in promoting cell migration through interactions with its transmembrane …

The major cause of cancer mortality is the metastatic spread of tumor cells that can occur via
multiple routes, including the lymphatic vasculature. Recent research has indicated that …

The high mortality rates associated with cancer can be attributed to the metastatic spread of
tumor cells from the site of their origin. Tumor cells invade either the blood or lymphatic …