Distant organ metastasis is the most important factor in determining patient survival in
cancer. This is thought to occur via the body's own systems for transporting fluid and cells …

The presence of metastases in regional lymph nodes is a strong indicator of poor patient
survival. A number of clinical and experimental studies suggest that tumor-induced …

The pace of research into the lymphatic system continues to accelerate with the availability
of new molecular markers. One such marker, LYVE‐1, the lymphatic receptor for the …

The field of lymphatic research has been recently invigorated by the identification of genes
and mechanisms that control various aspects of lymphatic development. We are beginning …

The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial
fluid and proteins, and is an important point of entry for leukocytes and tumor cells. The …

Lymphatic complications are common side effects of mammalian target of rapamycin
(mTOR) inhibitor-based immunosuppression in kidney transplantation. Therefore, we …

Early metastasis to lymph nodes is a frequent complication in human breast cancer.
However, the extent to which this depends on lymphangiogenesis or on invasion of existing …

For metastasis to occur, tumor cells must first detach from their tissue of origin. This requires
altering both the tissue of origin and the cancer cell. Once detached, cancer cells in …

Extracellular proteolysis is an absolute requirement for new blood vessel formation, a
process known as angiogenesis. This review will examine the role of the matrix …

Abstract Neuropilin‐1 (Np1) and neuropilin‐2 (Np2) are transmembrane glycoproteins with
large extracellular domains that interact with both class 3 semaphorins and vascular …