[HTML][HTML] Impact of testosterone on Alzheimer's disease

VE Bianchi - The World Journal of Men's Health, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a neurodegenerative disease responsible for almost half of all
dementia cases in the world and progressively increasing. The etiopathology includes …

The potential roles of redox enzymes in Alzheimer's disease: focus on thioredoxin

J Jia, X Zeng, G Xu, Z Wang - ASN neuro, 2021 - journals.sagepub.com
Alzheimer's disease (AD) is the most common neurodegenerative diseases. Increasing
studies have demonstrated the critical importance for redox proteins mediating neuronal …

Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice

Y Hou, W Zhao, H Yu, F Zhang, HT Zhang, Y Zhou - Phytomedicine, 2022 - Elsevier
Background Estrogen deficiency leads to mitochondrial defects that precede Alzheimer's
disease (AD)-associated pathological changes in a postmenopausal mouse model …

Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's disease

H Depypere, A Vergallo, P Lemercier… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction This increasing body of literature indicates that menopause hormonal
replacement therapy (MHT) may substantially mitigate the risk of developing late‐life …

Steroid hormones: risk and resilience in women's Alzheimer disease

N Calvo, G Einstein - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
More women have Alzheimer disease (AD) than men, but the reasons for this phenomenon
are still unknown. Including women in clinical research and studying their biology is key to …

Ovariectomy-induced hormone deprivation aggravates Aβ1-42 deposition in the basolateral amygdala and cholinergic fiber loss in the cortex but not cognitive …

S Farkas, A Szabó, B Török, C Sólyomvári… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease is the most common type of dementia, being highly prevalent in elderly
women. The advanced progression may be due to decreased hormone synthesis during …

Estrogen deficiency induces mitochondrial damage prior to emergence of cognitive deficits in a postmenopausal mouse model

W Zhao, Y Hou, X Song, L Wang, F Zhang… - Frontiers in aging …, 2021 - frontiersin.org
Background: Estrogen deficiency contributes to the development of Alzheimer's disease
(AD) in menopausal women. In the current study, we examined the impact of estrogen …

Sex and Sleep Disruption as Contributing Factors in Alzheimer's Disease

CE Johnson, MJ Duncan… - Journal of Alzheimer's …, 2024 - content.iospress.com
Alzheimer's disease (AD) affects more women than men, with women throughout the
menopausal transition potentially being the most under researched and at-risk group. Sleep …

The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9–12 Vitamins

G Pourié, N Martin, JL Daval, JM Alberto… - International journal of …, 2020 - mdpi.com
A deficiency in B-vitamins is known to lead to persistent developmental defects in various
organs during early life. The nervous system is particularly affected with functional …

Estradiol improves behavior in FAD transgenic mice that express APOE3 but not APOE4 after ovariectomy

D Balu, AC Valencia-Olvera, A Deshpande… - Frontiers in …, 2024 - frontiersin.org
Increasing evidence suggests that female individuals have a higher Alzheimer's disease
(AD) risk associated with post-menopausal loss of circulating estradiol (E2). However …