Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer's disease (AD) have
been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …

Alzheimer's disease (AD) is a central nervous system disease that can lead to cognitive
impairment and progressive memory loss. An increasing number of studies have shown that …

Insulin resistance is one of the etiologies of type 2 diabetes mellitus (T2DM) and has been
suggested to contribute to the development of Alzheimer's disease by promoting amyloid-β …

Accumulating evidence suggests that glutathione loss is closely associated with the
progression of neurodegenerative disorders. Here, we found that the neuronal conditional …

Alzheimer's disease (AD) is characterised by age-related cognitive decline. Brain
accumulation of amyloid-β plaques and tau tangles is required for a neuropathological AD …

The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the
deposition of the amyloid β peptide (Aβ) in Alzheimer's disease (AD). Missing have been in …

Among the central features of Alzheimer's disease (AD) progression are altered levels of the
neuropeptide somatostatin (SST), and the colocalisation of SST-positive interneurons (SST …

INTRODUCTION Abnormalities of neuropeptides (NPs) that play important roles in
modulating neuronal activities are commonly observed in Alzheimer's disease (AD). We …

Results Neuronal GCLC knockout leads to brain atrophy accompanied by neuronal cell
death. To examine how the declines in GCLC and glutathione might affect brain …

Experimental animal models play an essential role in the study of pathogenic mechanisms
and development of novel therapies for diseases. Many disease models are developed by …