[HTML][HTML] Recent advances in the modeling of Alzheimer's disease
H Sasaguri, S Hashimoto, N Watamura… - Frontiers in …, 2022 - frontiersin.org
Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer's disease (AD) have
been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …
been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …
Intestinal Flora affect Alzheimer's disease by regulating endogenous hormones
Y Wu, Z Hang, T Lei, H Du - Neurochemical Research, 2022 - Springer
Alzheimer's disease (AD) is a central nervous system disease that can lead to cognitive
impairment and progressive memory loss. An increasing number of studies have shown that …
impairment and progressive memory loss. An increasing number of studies have shown that …
[HTML][HTML] Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation
S Hashimoto, Y Matsuba, M Takahashi, N Kamano… - Scientific Reports, 2023 - nature.com
Accumulating evidence suggests that glutathione loss is closely associated with the
progression of neurodegenerative disorders. Here, we found that the neuronal conditional …
progression of neurodegenerative disorders. Here, we found that the neuronal conditional …
[HTML][HTML] Molecular mechanisms of obesity-induced development of insulin resistance and promotion of amyloid-β accumulation: Dietary therapy using weak organic …
Y Marunaka - Biomolecules, 2023 - mdpi.com
Insulin resistance is one of the etiologies of type 2 diabetes mellitus (T2DM) and has been
suggested to contribute to the development of Alzheimer's disease by promoting amyloid-β …
suggested to contribute to the development of Alzheimer's disease by promoting amyloid-β …
[HTML][HTML] Interrogation of the human cortical peptidome uncovers cell-type specific signatures of cognitive resilience against Alzheimer's disease
GR Morgan, BC Carlyle - Scientific Reports, 2024 - nature.com
Alzheimer's disease (AD) is characterised by age-related cognitive decline. Brain
accumulation of amyloid-β plaques and tau tangles is required for a neuropathological AD …
accumulation of amyloid-β plaques and tau tangles is required for a neuropathological AD …
[HTML][HTML] Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation
D Williams, BQ Yan, H Wang, L Negm, C Sackmann… - Scientific Reports, 2023 - nature.com
The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the
deposition of the amyloid β peptide (Aβ) in Alzheimer's disease (AD). Missing have been in …
deposition of the amyloid β peptide (Aβ) in Alzheimer's disease (AD). Missing have been in …
Somatostatin and the pathophysiology of Alzheimer's disease
VN Almeida - Ageing Research Reviews, 2024 - Elsevier
Among the central features of Alzheimer's disease (AD) progression are altered levels of the
neuropeptide somatostatin (SST), and the colocalisation of SST-positive interneurons (SST …
neuropeptide somatostatin (SST), and the colocalisation of SST-positive interneurons (SST …
Single‐cell sequencing of entorhinal cortex reveals widespread disruption of neuropeptide networks in Alzheimer's disease
INTRODUCTION Abnormalities of neuropeptides (NPs) that play important roles in
modulating neuronal activities are commonly observed in Alzheimer's disease (AD). We …
modulating neuronal activities are commonly observed in Alzheimer's disease (AD). We …
[PDF][PDF] Are the N-terminal derivatives of IGF-I neuropeptides agents for the treatment of Alzheimer's disease
Abstract Glycine-proline-glutamate (GPE) and cycloprolylglycine (cPG) are naturally cleaved
peptides of the insulinlike growth factor I (IGF-I) in the central nervous system. The …
peptides of the insulinlike growth factor I (IGF-I) in the central nervous system. The …
Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation
橋本翔子 - 2023 - shiga-med.repo.nii.ac.jp
Results Neuronal GCLC knockout leads to brain atrophy accompanied by neuronal cell
death. To examine how the declines in GCLC and glutathione might affect brain …
death. To examine how the declines in GCLC and glutathione might affect brain …