Although the prevalence of dementia continues to increase worldwide, incidence in the
western world might have decreased as a result of better vascular care and improved brain …

Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

Recent developments of PET amyloid ligands have made it possible to visualize the
presence of Aβ deposition in the brain of living participants and to assess the consequences …

Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …

Background White matter hyperintensities (WMH) are very frequent in older adults and
associated with worse cognitive performance. Little is known about the links between WMH …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia. Beta-amyloid (Aβ) deposition and neurofibrillary tangles (NFTs) …

Importance Because deposition of cerebral β-amyloid (Aβ) seems to be a key initiating event
in Alzheimer disease (AD), factors associated with increased deposition are of great interest …

White matter alterations are present in the majority of patients with Alzheimer's disease type
dementia. However, the spatiotemporal pattern of white matter changes preceding dementia …

Importance Identifying risk factors for increased β-amyloid (Aβ) deposition is important for
targeting individuals most at risk for developing Alzheimer disease and informing clinical …