Alzheimer's disease

P Scheltens, K Blennow, MMB Breteler, B De Strooper… - The Lancet, 2016 - thelancet.com
Although the prevalence of dementia continues to increase worldwide, incidence in the
western world might have decreased as a result of better vascular care and improved brain …

[HTML][HTML] Ageing, cellular senescence and neurodegenerative disease

M Kritsilis, S V. Rizou, PN Koutsoudaki… - International journal of …, 2018 - mdpi.com
Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Interactive associations of vascular risk and β-amyloid burden with cognitive decline in clinically normal elderly individuals: findings from the Harvard Aging Brain …

JS Rabin, AP Schultz, T Hedden, A Viswanathan… - JAMA …, 2018 - jamanetwork.com
Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

[HTML][HTML] Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease

G Chételat, R La Joie, N Villain, A Perrotin… - NeuroImage: Clinical, 2013 - Elsevier
Recent developments of PET amyloid ligands have made it possible to visualize the
presence of Aβ deposition in the brain of living participants and to assess the consequences …

Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly

P Vemuri, TG Lesnick, SA Przybelski, DS Knopman… - Brain, 2015 - academic.oup.com
Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …

[HTML][HTML] White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition

A Garnier-Crussard, S Bougacha, M Wirth… - Alzheimer's research & …, 2020 - Springer
Background White matter hyperintensities (WMH) are very frequent in older adults and
associated with worse cognitive performance. Little is known about the links between WMH …

SPECT and PET imaging in Alzheimer's disease

V Valotassiou, J Malamitsi, J Papatriantafyllou… - Annals of nuclear …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia. Beta-amyloid (Aβ) deposition and neurofibrillary tangles (NFTs) …

Associations between serum cholesterol levels and cerebral amyloidosis

B Reed, S Villeneuve, W Mack, C DeCarli… - JAMA …, 2014 - jamanetwork.com
Importance Because deposition of cerebral β-amyloid (Aβ) seems to be a key initiating event
in Alzheimer disease (AD), factors associated with increased deposition are of great interest …

White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease

MÁ Araque Caballero, M Suárez-Calvet, M Duering… - Brain, 2018 - academic.oup.com
White matter alterations are present in the majority of patients with Alzheimer's disease type
dementia. However, the spatiotemporal pattern of white matter changes preceding dementia …

Risk factors for β-amyloid deposition in healthy aging: vascular and genetic effects

KM Rodrigue, JR Rieck, KM Kennedy… - JAMA …, 2013 - jamanetwork.com
Importance Identifying risk factors for increased β-amyloid (Aβ) deposition is important for
targeting individuals most at risk for developing Alzheimer disease and informing clinical …