[HTML][HTML] Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications
The global propagation of SARS-CoV-2 leads to an unprecedented public health
emergency. Despite that the lungs are the primary organ targeted by COVID-19, systemic …
emergency. Despite that the lungs are the primary organ targeted by COVID-19, systemic …
Persistent endotheliopathy in the pathogenesis of long COVID syndrome
H Fogarty, L Townsend, H Morrin… - … of thrombosis and …, 2021 - Wiley Online Library
Background Persistent symptoms including breathlessness, fatigue, and decreased exercise
tolerance have been reported in patients after acute SARS‐CoV‐2 infection. The biological …
tolerance have been reported in patients after acute SARS‐CoV‐2 infection. The biological …
Platelet activation and thrombosis in COVID-19
Although thrombosis frequently occurs in infectious diseases, the coagulopathy associated
with COVID-19 has unique characteristics. Compared with bacterial sepsis, COVID-19 …
with COVID-19 has unique characteristics. Compared with bacterial sepsis, COVID-19 …
Sustained VWF‐ADAMTS‐13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction
Background Prolonged recovery is common after acute SARS‐CoV‐2 infection; however,
the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown …
the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown …
Status of major hemostatic components in the setting of COVID-19: the effect on endothelium, platelets, coagulation factors, fibrinolytic system, and complement
The coagulation, fibrinolytic, anticoagulation, and complement systems are in delicate
balance with the vessel wall endothelium ensuring appropriate hemostasis. Coagulopathy …
balance with the vessel wall endothelium ensuring appropriate hemostasis. Coagulopathy …
NLRP3 inflammasome and interleukin-1 contributions to COVID-19-associated coagulopathy and immunothrombosis
N Potere, E Garrad, Y Kanthi, M Di Nisio… - Cardiovascular …, 2023 - academic.oup.com
Immunothrombosis—immune-mediated activation of coagulation—is protective against
pathogens, but excessive immunothrombosis can result in pathological thrombosis and …
pathogens, but excessive immunothrombosis can result in pathological thrombosis and …
Pathophysiology of COVID-19: critical role of hemostasis
SA Andrade, DA de Souza, AL Torres… - Frontiers in cellular …, 2022 - frontiersin.org
The COVID-19 pandemic, caused by SARS-CoV-2, had its first cases identified in late 2019
and was considered a clinical pandemic in March 2020. In March 2022, more than 500 …
and was considered a clinical pandemic in March 2020. In March 2022, more than 500 …
[HTML][HTML] Breast cancer cells mediate endothelial cell activation, promoting von Willebrand factor release, tumor adhesion, and transendothelial migration
Background Breast cancer results in a three‐to four‐fold increased risk of venous
thromboembolism (VTE), which is associated with reduced patient survival. Despite this, the …
thromboembolism (VTE), which is associated with reduced patient survival. Despite this, the …
Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2–induced lung exudative vasculitis and predicts COVID-19 severity
C Iwamura, K Hirahara, M Kiuchi… - Proceedings of the …, 2022 - National Acad Sciences
The mortality of coronavirus disease 2019 (COVID-19) is strongly correlated with pulmonary
vascular pathology accompanied by severe acute respiratory syndrome coronavirus 2 …
vascular pathology accompanied by severe acute respiratory syndrome coronavirus 2 …
Investigating the relationship between vitamin D and persistent symptoms following SARS-CoV-2 infection
L Townsend, AH Dyer, P McCluskey, K O'Brien… - Nutrients, 2021 - mdpi.com
The emergence of persistent symptoms following SARS-CoV-2 infection, known as long
COVID, is providing a new challenge to healthcare systems. The cardinal features are …
COVID, is providing a new challenge to healthcare systems. The cardinal features are …